Mannitol

[cshamb]

I tried taking Mannitol. Maybe 1/2 tsp in my oatmeal but have stomach upset with loose bowels. Any suggestions? Thanks

[Hidden]

cshamb,

I do not take mannitol, but I do take xylitol which is a similar sugar alcohol or polyol and can have similar gastrointestinal effects. With time, I was able to increase my xylitol, but what was the most helpful was to mix my xylitol into drinking water or some other drink. I specifically use a 500ml bottle of water which I drink about two to three ounces from it. I then add the amount of xylitol I want to take for the day and completely dissolve the xylitol in the water bottle by shaking. I then replace the missing two to three ounces of water with a flavored sports drink like Gatorade or Powerade to add a little flavor. I sip this bottle throughout the day and this affords a slower release of the xylitol which helps to minimize or eliminate the gastro issues.

Art

[KERRINGTON in reply to Hidden]

You just helped me out too ! I couldn't find travel size packets of mannitol, but can for xylitol. I hadn't known it works like mannitol. What brand do you use ? Thanks !

[Hidden in reply to KERRINGTON]

Well, I don't know that it works just like mannitol, because I have seen no studies that indicate that xylitol affects the blood brain barrier as mannitol is purported to do nor have I seen any to indicate that it can potentially affect alpha synuclein aggregation. What they have in common, based on studies is that they both have the potential to boost hydrogen sulfide and butyrate production in conjunction with the proper gut bacteria. The butyrate, aside from having anti-inflammatory propeties then also acts as a hystone deacetylase inhibitor which is very important for PWPs and cancer patients among other health issues.

They both increase two other short chain fatty acids in the forms of propionate and acetate.

As far as brands I use, right now I am using NOW brand which is derived from corn and previously I have used another brand which is derived from the birch tree and is called Garden of Health Products Kosher Birch Xylitol .

[KERRINGTON in reply to Hidden]

Thanks for elaborating on that !

[alexask in reply to Hidden]

I am wondering whether there would be any benefit to inhaling Mannitol nasally?

[Hidden in reply to alexask]

I am doubtful that such a study in humans would ever come along and it will likely have to be somebody who feels desperate enough to try it on their own in order to get that ball rolling.

I have often wondered the same about ibuprofen because of its fairly potent anti-inflammatory qualities and at least intranasal ibuprofen has already been tried in MPTP mice to good effect!

ncbi.nlm.nih.gov/pmc/articl...

ncbi.nlm.nih.gov/pubmed/244...

Wouldn't it be great if you go to the pharmacy and tell your pharmacist that you have PD, migraine or Alzheimer's Disease and they tell you, " to go to aisle 6 on the right about half way down at eye level and you will find ibuprofen nasal spray that will quickly reduce your symptoms in about 5 minutes"!

Again, a human study seems fairly unlikely for ibuprofen delivered intranasally, but ibuprofen has a comparatively good safety profile and has proven anti-inflammatory properties and the medical field already has a tremendous amount of practical experience with it, but the cost of such a trial would be cost prohibitive for such an inexpensive drug which leaves no incentive for any company to ever pay to do such testing. Realistically, it seems like it could be delivered very easily using an ultrasonic vaporizer for high dose and a nebulizer for lower dose delivery.

I'm just thinking out loud here!

Art

[alexask in reply to Hidden]

Interesting. I also seem to remember that Joe/Sunvox made up a nasal Trehalose concoction. I am quite tempted to whizz a mixture of Mannitol/Trehalose and Ibuprofen in my electric coffee grinder and snort. Not something I could really take to work though.

[Hidden in reply to alexask]

That was just me thinking out loud, not recommending that idea. I like to self experiment and the safety of inhaled ibuprofen in humans is unkown, so I wouldn't try it myself and definitely would not recommend it to others!

Art

[Despe in reply to Hidden]

Art, here is a "silly" question. People take ibuprofen for headache and the pain subsides. How does ibuprofen stop the headache, does it reach the brain?

[Hidden in reply to Despe]

Not a silly question and I don't think that every aspect of the method of action of ibuprofen is known. What is known is that it inhibits enzymes in the family cyclooxygenase (COX).

Here is a very brief article on the subject of the method of action of ibuprofen:

news-medical.net/health/Ibu...

To answer the question about ibuprofen and does it reach the brain, there is this:

ncbi.nlm.nih.gov/pubmed/167...

Art

[Despe in reply to Hidden]

Thanks, Art. At a younger age, I suffered hereditary severe headaches. I used to take 1600 mg prescription MOTRIN. It did wonders for my pain, but I lost my intestinal health to it. It must have been reaching my brain, I guess.

[Hidden in reply to Despe]

Yes, the gastro issues are a common problem for some people, but not others and this is why I mentioned topical application of ibu as one potential method to avoid that problem.

One thing I wonder about is if you apply topical ibu to the entire spine if it will find its way into the cerebrospinal fluid and further to the brain in order to bypass the stomach and the inherent problems related to that pathway????

[Despe in reply to Hidden]

It might. Our family doctor wanted to prescribe dermal ibuprofen. I will give it a try. Never heard of topical application before until our doctor mentioned it.

[Hidden in reply to Despe]

It's been around for at least a decade or longer. I think I first read about it about 15 years ago. Not super common in the US, but other countries use it.

Art

[glenandgerry in reply to Hidden]

What amount of xylitol do you mix into the 500ml bottle Art?

[Hidden in reply to glenandgerry]

12 to 15 grams is the amount of xylitol I mix into my drink.

[glenandgerry in reply to Hidden]

Many thanks 😊

[Motherfather in reply to glenandgerry]

20 grams for mannitol..no more than that..same put it in the 500 ml bottle.better to have it with food,

[glenandgerry in reply to Motherfather]

Thank you. My husband has been taking mannitol again. Last year I tried him on half a teaspoon but his stomach just couldn't tolerate it. A year later I decided to try it again and he now seems to tolerate it much better. Don't know if that has anything to do with him taking probiotics and yoghurt every day. However he's only taking 1 teaspoon (4 grams) in the morning and another teaspoon in the afternoon which I don't think is enough but he can't tolerate any more than this. I've just run out of mannitol so am trying him on xylitol the way easilly takes it throughout the day. I'm hoping this will be a good combination together with the Advanced Orthomolecular Research probiotics. 😊

[Motherfather in reply to glenandgerry]

hi glen and gerry well not sure about that xylitol as i never tried it .i take yogurt every day with fruit in it blueberries and cherries.both frozen.as you can buy then all year and also probiotics every day but i think he needs at least 15 grams a day..with food i also take b1 thiamine 2000 mg and 500 mg of b3.im starting to get more good days now.you can give it to him 5 times a day spread it out a bit i have ordered 1 kilo of powered thiamine ill mix the 2 together and see what happens.im 71 and still walk more than 10 kl a day plus other exercise push ups etc etc.your husband needs to get out and go for long walks.you just walk through the pain.put some head phones on him with a radio he will enjoy it more.regards .

[Kia17]

Art

How does Mannitol interact with insulin. Same story as glucose! Any idea?

Thank you

Kia

[Hidden in reply to Kia17]

I'm not familiar with how they react, but I suspect, like other sugar alcohols, it is broken down much slower than glucose through the fermentation process and this in turn greatly lessens the potential for a sugar/glucose spike which in turn greatly reduces the potential for an insulin spike which in turn greatly reduces the potential for an inflammatory response! The sugar alcohols in general have a much lower glycemic index rating than sugar.

Art

[Kia17 in reply to Hidden]

Art

Thanks very much for your input.

Kia

[alaynedellow in reply to Kia17]

Mannitol is used as sweetner in diabetic products so it should be ok to use for you as a diabetic without affecting your insulin levels.

[park_bear]

I take with Beano which resolves the flatulence problem.

[Toogood in reply to park_bear]

What’s beano...

[park_bear in reply to Toogood]

beanogas.com/

[Toogood in reply to park_bear]

Thankyou

[JohnPepper]

There is only one way that I know of to slow down or even reverse the progression of Pd and that is EXERCISE!

Look at my PROFILE and look at my website, reverseparkinsons.net. Contact me and see if I can help you. It COSTS NOTHING!

[glenandgerry in reply to JohnPepper]

Hello again John, my husband and I met up with you a few years ago at Ashford, Middx. Unfortunately Glen is unable to do any exercise as he has excruciating back pain which travels through his thigh, down through his total knee joint replacement into his calf and culminating in a very sore ankle and foot. He has previously had 4 spinal injections over the past 5 years with varying degrees of success, but is now presently awaiting an MRI later this month and then an appointment with the specialist in September. Until then he is on morphine and tramadol for the pain. It's such a shame he is unable to move - he's not even able to do simple Qigong exercises Consequently I'm looking at every other alternative to try and help his Parkinson's symptoms. Although at the moment he says they are the least of his troubles.

[JohnPepper in reply to glenandgerry]

Hi. Has Glen got a prolapsed disc? I have had 2 prolapsed discs in the past. The first was removed in 1977 and the second in 1998. Both operations were a success and both took away the excruciating sciatic pain. I did not have a fusion in either case. Bone fusion causes more problems because the vertebrae are not mean to be joined together.

[glenandgerry in reply to JohnPepper]

The medical professionals have diagnosed spinal stenosis in the past but Glen says this time the pain is different. He is due to have an MRI scan next week so we should know more thereafter.

[Smokeypurple]

Have you completed the Clinicrowd questionnaire to see what amount they suggest taking?

I had a reaction at first but I think increasing the dose very slowly gram by gram can help.

I started taking it in the morning but experienced embarrassing wind as a side effect so now take it before bed and my body seems to deal with it overnight.

[AmyLindy in reply to Smokeypurple]

Makes sense- take mannitol at night instead!