Cellular biochemistry of Thiamine

As part of the Thiamine story found this.

pubs.niaaa.nih.gov/publicat...

Vitamin B1 supplement needed by heavy drinkers!

[gbb4692]

What counts as a heavy drinker? 1-2 drinks socially a couple of beers at a game? I have never gotten a good answer.

[bassofspades in reply to gbb4692]

if you have to ask...LOL, just kidding! Heavy is you drink multiple drinks every day, and that includes beer. Or if you drink to get drunk. One or 2 socially is not "heavy", neither is a small glass of wine in the evening.

[wriga]

Good article, well worth reading and keeping even for non alcoholics.

[Hidden]

Try this on... L/C “works” because it bypasses Tyrosine to l-dopa conversion and cell can still convert l-dopa to Dopamine. Thiamine fixes the Tyrosine to l-dopa conversion step. Tyrosine supplements don’t work

[Hidden in reply to Hidden]

Mao-b or COMT inhibitors preserve Dopamine and help clean up synapses. Thiamine helps clean up synapses. In both cases it’s down to the biochemistry of Thiamine!?....

[Hidden]

Some more info on how thiamine is absorbed and used

ncbi.nlm.nih.gov/pmc/articl...