Is anyone taking Mirapex / pramipexole? Based on this early phase trial with good results I wanted to try it.

[p-oui]

P2B001 combines low-dose pramipexole and rasagiline, sold under the brand names Mirapex and Azilect.

The trial included these two drugs: pramipexole 0.3 mg plus rasagiline 0.75 mg, or pramipexole 0.6 mg and rasagiline 0.75 mg

Currently taking rasagaline 1mg

Is anyone taking something close to this combination? My main symptom is worsening tremor.

parkinsonsnewstoday.com/201...

[p-oui]

The phase II results

parkinsonsnewstoday.com/201...

[Hikoi]

P-oui

Agonists in general seem to help tremor. I cant get rasageline where i live so not much help to you. However as an aside - recently the neuro switched my requip to pramipexole because he said it may give better control of my tremor and it has..

[p-oui in reply to Hikoi]

Hikoi, I tried the pramipexole with negative results and no positive results. I wanted to sleep all the time.

[Hikoi in reply to p-oui]

Yes agonists do make you sleepy. I think it took months if not a year to get really settled on ropinerole and now I have changed to pramipexole I fall asleep regularly when I sit down especially after my mid day meds. Just wish it was night sleep rather than day time sleep!

[p-oui in reply to Hikoi]

My heart also started to flutter... what an ordeal this med was for me! I am going to start taking Thiamine. What do you think about that Hikoi?

[Hikoi in reply to p-oui]

I will watch your experience with interest. I am tempted myself to try it but must wait until the trial I am on is completed. I am also looking forward to the promised article by Simon.

[Sane1]

Thanks for posting. Will be watching for results and hopefully marketing. I have been taking the higher dose Mirapex ER along with the azilect since diagnosis 2014. Have been doing well but am just starting to get some pesky side effects. This sounds like it may be a good fit.

[Klayhee]

I've been on Mirapex for over a year with no problems. I love it. I was a little sleepy getting on it, but that went away after the first week. Good luck.

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