Parkinson's Movement
13,804 members12,365 posts

added Vitamin D3 back into my supplements

…daily supplementation with 1200 IU vitamin D3 for 12 mo significantly prevented the deterioration of PD….https://academic.oup.com/ajcn/article/97/5/1004/4577000…. as measured with the HY stage, UPDRS part II and total, and some domains of the PDQ39, with no apparent increase in risk of hypercalcemia or other adverse events during the study period. A point estimate of the number needed to treat was 6 patients for no worsening or improvement in the HY stage, which was considered very effective. To the best of our knowledge, this is the first randomized trial to examine the effects of vitamin D3 in patients with PD. However, a meta-analysis showed that supplemental vitamin D for older adults who participated in randomized controlled trials consistently showed beneficial muscle effects on strength and balance (27). Therefore, it cannot be distinguished whether vitamin D supplementation specifically delays the progression of PD or whether it just nonspecifically improves muscle strength and balance in older adults.

23 Replies
oldestnewest

I take 10000 IU daily. Last time I checked my levels were in the middle of the desirable range.

3 likes
Reply

"Very high levels of vitamin D (above 10,000 IU a day) may cause kidney and tissue damage. Evidence of risks at lower levels is limited, but some studies offer tentative signals about adverse health effects. The report also notes that standards for vitamin D blood test results have not been based on rigorous studies and could lead to doctors diagnosing vitamin D deficiency when people have enough."

aarp.org/health/drugs-suppl...

2 likes
Reply

in my opinion I would take about 1000 IU max 4000 IU a day and no more.could be dangerous in long term.

3 likes
Reply

“New research documents, however, that the dangers of vitamin D have been exaggerated, and natural vitamin D3 (also known as cholecalciferol) has much less toxic potential than commonly thought. The Canadian vitamin D expert, Dr. Reinhold Vieth, has found vitamin D3 doses up to 10,000 IU per day to be safe in individuals who do not have conditions that predispose them to high blood calcium (such as hyperparathyroidism and acidosis). Further, fully documented cases of toxicity have only occurred with intakes of 40,000 IU per day or more. This low toxicity of vitamin D is not so surprising when we realize that a light-skinned person in tee shirt and shorts outdoors during the summer in New Jersey can produce 12,000 IU of vitamin D within 20 minutes.....

Vitamin D is both more important and safer than ever expected, yet as with all fat-soluble vitamins, it is retained in the body and thus doses above 4000 IU, the current U.S. official “Upper Safe Limit” should be used under proper supervision…..

While vitamin D is clearly safer than previously thought, it is always wise to consult with your healthcare professional to determine your specific supplementation program. Individuals with special health concerns and those with disorders such as kidney failure, a history of kidney stones, high blood calcium, hyperparathyroidism, sarcoidosis, oat cell carcinoma, non-Hodgkin’s lymphoma, or leukemia should not use vitamin D supplements unless under clear guidance of their physician.”

betterbones.com/bone-nutrit...

Author: Susan E. Brown, PhD, is a medical anthropologist, a New York State Certified Nutritionist, and the author of Better Bones, Better Body — the first comprehensive look at natural bone health. She has more than 20 years of experience in clinical nutrition, bone health research, and lay and health professional education. She has consulted widely on socioeconomic, cultural, educational, and health issues. Dr. Brown has taught in North and South American universities and authored numerous academic and popular articles. For more information, see Dr. Brown’s biography.

Consults at the Center for Better Bones

Susan E. Brown, PhD conducts consultations at the Center for Better Bones in East Syracuse, New York, and via telephone with patients world-wide. Dr. Brown will assist you in estimating your real risk of experiencing an osteoporotic fracture, help you understand your bone-health-related test results, determine whether further assessments are needed by your physician to detect any underlying medical or biochemical causes of your bone loss, estimate your current rate of bone loss, and work with you to create a personalized lifestyle, diet, and supplement plan to support healthy bone growth, bone regeneration, and overall wellness. Initial consultations are 60 minutes long and follow-up appointments range from 15-60 minutes. For more information see our page on consultations.

6 likes
Reply

Great info Roy. I’ve been taking 10,000IU of D3 for years. Dr. Oz spoke about this at least 5 yrs ago. Thx

3 likes
Reply

"...cancer inst isnt going to say anything good about supplements not when thers billions to be made on their (OFFICIAL) treatments of chemo,radiation,and surgery! theres thousands of reasearch papers from all over the world showing that the cancer protection from vit d3 usually best when your levels are at the higher end of testing range 80 to 100. 5k iu a day will get you around a 50 on testing. I personally use 15k a day and my range is about 90. Now if i were to go out in the sun in the summer in my bathing suit for 30 min to an hour my body would make on its own about 10 to 15k iu of vit d. so if you didnt need that much your body wouldnt make that much , that simple! nature must deem it pretty important to our well being and for these two reasearchers to say that your not suppose to get the RDA every day is just plain ignorant. there are 90 essential nutrients you need everyday.16 vit , 60 minerals, 2 to 3 fatty acids. lacking in any one of them for periods of time leads to system, breakdowns and disease. IN todays day and age you cant get all your nutrients from food. if its not in the soil when the food is grown its not in the plant when you eat it. For me ill take my supplements everyday and ill probably wont need your expensive pharmacueticals!"

excerpt/comment at bottom of page - emaxhealth.com/8782/dr-oz-v...

6 likes
Reply

Thing about Vit D supplements, people do tend to feel better on them. It causes calcium to precipitate out of where you want it, ie bones, and into soft tissues which has a numbing effect. It also uses up magnesium in the conversion process.

If you're taking it, make sure you're taking plenty of magnesium and retinol. I have my dad on Rosita's Cod Liver Oil, it has the right ratio of natural Vitamin A to D. I'm not sure he can even be in the sun anymore now he's on levodopa, I've heard it can cause skin cancer :(

1 like
Reply

Hi Dee. I think levodopa is not the cause for 3 or 4 fold risk of melanoma, but PD itself is.

1 like
Reply

That's very interesting. I came across an interview yesterday explaining why our ancestors, who spent a lot of time in the sun, didn't get skin cancers as much as we do now. I can't remember all of the ins and outs, but it would make so much sense for PWP to be at risk.

Reply

If anyone is curious, retinol (from animals, not beta-carotene) is what enables us to go in the sun without getting skin cancer. Sun exposure produces hydrogen peroxide and retinol is what neutralises it. As I said, it would make sense for PWP to have that risk, though I'm going to take a look at levodopa and see if it tanks retinol in the liver.

Reply

Let me just disagree a bit here. Beta-carotene is great, alcohol is the worst, and retinol is meh.

livestrong.com/article/4900...

Reply

How do we know this about our ancestors? Are we talking 100 yrs. ago or much further. My grandma, who was 86 when she died in '72, was out in the sun working in gardens when I was 8-10. She never had skin cancer that we know of. Died of hardening of the arteries. My mom was lighter skinned than her and walked alot, or worked outside and may have had skin cancer, little ones, but did have Sarcoma on her leg, and a spot of lung cancer. Both surgeries were sucessful, just radiation after. Died of brain bleed at 89. My husband has PD and the Dermatologist has given blue light treatments on arms and head (not much hair). He has had small spots if cancer and before PD had a growing Sarcoma below his eye. Removed and fine. I'm not in the sun much but was as a teen, no sunscreen then, but over the years the sun came thru the window as I drove and have recently had cancer removed from the side of my nose where the sun would hit. The surgery dug out a hole but this Dr. did a figure 8 flap surgery and you can hardly tell now. It will be numb and itchy tho. I've had small spots burned off and another surgery from a brown spot years ago and it was maybe melenoma so that Dr. sent me for further surgery to get it all. Great job, can't tell but Medicare at first thought it was a face lift or something. My point is be careful if sun coming thru a car window. M.A. in USA.

1 like
Reply

WRONG!: "It causes calcium to precipitate out of where you want it, ie bones, and into soft tissues which has a numbing effect."

That statement is the exact opposite of the truth: Vitamin D is needed to get calcium out of the bloodstream into the bones. See my writings, all referenced to medical journals:

Vitamins and Minerals for Bone Health and Reduced Risk of Cancer

tinyurl.com/hya5dwd

Vitamin K: Unsung and Essential

tinyurl.com/yd9l4j3q

Details of the vitamins and minerals that improve bone strength, reduce fracture risk, prevent hardening of the arteries, improve cardiovascular outcomes, and reduce cancer risk.

What You Need to Know to Reduce Risk of Hip Fracture and Cardiovascular Disease

tinyurl.com/y8o9jy8u

A review of the foregoing + calcium deposits on teeth as a sign of trouble.

1 like
Reply

I don't think we'll ever solve the great Hormone D 'supplement' debate, if you feel better on it, have better numbers, take your mag, boron and K2 with it, then it's good for you and it works for you.

A snippet from your last link:

Regarding hip fractures, a 50 % higher risk of hip fracture was observed in subjects with both low vitamin K1 and D compared with subjects with high vitamin K1 and D

D comes in two form, active and storage. There's no benefit in having high storage numbers, if it's stored there's a reason, ie high calcium, not enough magnesium to flip it to active etc. If you're high calcium, it's mostly likely come out of the bones, and probably suggests low maggy too. These two things will keep D low and bone mineral density low.

Edit: Just to say sorry you're absolutely right about K2. That's why it's important to make sure you have grassfed eggs/butter/milk.

That's just my take on it from personal experience :)

Reply

There is no debate. Regarding your statements beginning with "There's no benefit in having high storage numbers..." I will need journal references to take these assertions seriously.

Thank you for taking the time to read my writings.

Reply

sciencedaily.com/releases/2...

It's not the direct link, which is below the article, but summarises what these researchers found. Of course, there could be other studies that find the complete opposite, but naturally you'll find a 10-1 ratio of Retinol to D, in cod liver oil or beef liver, which suggests to me that's what we need as humans.

Reply

The report you cite merely states there is an optimum blood level of vitamin D. It provides zero support for your various contentions.

healthunlocked.com/parkinso...

"If the references fail to support the assertions claimed for them that is a fatal red flag. 'Falsus in unum, falsus in omnibus' "

Reply

amjmed.com/article/S0002-93...

'We found that, independent of demographic and conventional cardiovascular disease risk factors, an increase in serum 25(OH)D up to 21 ng/mL is associated with significant reduction in the risks of all-cause and cardiovascular disease mortality among healthy adults. We further report that an increase in serum 25(OH)D levels above 21 ng/mL offers statistically insignificant reduction in the risk of all-cause or cardiovascular disease mortality in healthy adults.'

There's four further studies below that state there's no benefit over 21/24 ng/ml. (21 is considered normal low as opposed to 'optimal')

There's also a trial that will look at fish oil v 2000IU of D. I might see if there's any results from that yet.

Reply

What you just posted is in accord with my prior statement: "The report you cite merely states there is an optimum blood level of vitamin D. It provides zero support for your various contentions."

These contentions:

"if it's [vit D] stored there's a reason, ie high calcium" reference?

"not enough magnesium to flip it to active" reference?

"If you're high calcium, it's mostly likely come out of the bones" reference?

"and probably suggests low maggy too." reference?

"These two things will keep D low" reference?

Not to mention this outright falsehood: "Vit D supplements ... causes calcium to precipitate out of where you want it, ie bones, and into soft tissues which has a numbing effect. " Got a reference for that?

Reply

Well that's a list! With all the ins and outs of Vitamin D, it's impact on magnesium, retinol (which impacts on ceruloplasmin which impacts on iron) that would be pages of references.

"not enough magnesium to flip it to active"

bmcmedicine.biomedcentral.c... -

High intake of total, dietary or supplemental magnesium was independently associated with significantly reduced risks of vitamin D deficiency and insufficiency respectively.

ncbi.nlm.nih.gov/pubmed/384...

We conclude that magnesium depletion may impair vitamin D metabolism.

"Vit D supplements ... causes calcium to precipitate out of where you want it, ie bones, and into soft tissues which has a numbing effect"

Vitamin D's action is to get calcium into the blood (not bones), it's retinol and co-factors like boron and K2 and, most importantly, magnesium that get calcium to where it should be and hold it there. Now if you're taking something, like say VitD, that tanks your retinol, uses up huge amound of magnesium converting from calcidiol (storage) to calcitriol (active, needed form) you're going to end up high calcium. Hence the above above references citing high levels of storage D and increase in mortality.

This will be my last post on the topic because I just don't have time to cite all my references (yes that's important, I know, anyone can make stuff up on the internet), but just to explain why I'm warning about it.

I don't want my dad taking Vitamin D supplements because of its calcium issues (that in itself is a warning to PWP), that it'll tank his vitamin A, it'll cause the iron-regulating enzyme ceruloplasmin to tank, it'll lower his magnesium even further. I'll give him cod liver oil, which comes with the retinol. Just a personal decision :)

chrismasterjohnphd.com/2009...

1 like
Reply

Wow

Reply

I just liked the way I “felt” and knowing studies support high normal serum levels. Placebo? Clinical benefit or calcium risk?

Reply

I took a course of 50,000 iu vit D over a short period of clinical supervision and brought my levels from low to high in less than 2 weeks - resolved depression and provided other intangible benefits I am certain!

Reply

You may also like...