ANYONE IN THIS TRIAL: Prothena PASADENA Phase 2 trial? Love to hear what you think - some say most promising PD trial.

[p-oui]

This trial will enroll 300 people and the Pharma company, ROCHE, is investing $600 Million into this trial. Trial is for those who have been diagnosed with PD within the last two years but are not yet taking dopaminergic medication. They can be on a monoamine oxidase-B inhibitor such as rasagiline (azilect) or selegiline.

For the first year, one-third of the cohort will receive placebo and one-third a low dose of antibody, 1,500 mg. The remainder will take a high dose, which will vary by body weight—3,500 mg for people under 65 kg; 4,500 for those 65 kg or heavier. The high dose is roughly equivalent to the highest dose tested in Phase 1, 60 mg/kg.

Is anyone on HU in this trial? If so, would be very helpful to hear about your experience!

For more information on the Prothena Phase 2 clinical study of PRX002/RG7935 in patients with Parkinson's disease, visit clinicaltrials.gov and search NCT #03100149.

[Juliegrace]

Can you supply a link to the study?

[jeffreyn in reply to Juliegrace]

Here is the link:

clinicaltrials.gov/ct2/show...

[p-oui in reply to jeffreyn]

Thank you Jeffreyn, here is another link to share with those interested in clinical trials scienceofparkinsons.com/201...

[p-oui in reply to Juliegrace]

a general link that is good: scienceofparkinsons.com/201...

[p-oui in reply to Juliegrace]

Just another point of interest: globenewswire.com/news-rele...

[rebtar]

I'm in the process of seeing if i qualify. Hopefully know more next week.

[p-oui in reply to rebtar]

rebtar, I am also getting screened and should know more next week also. Do you know anyone who is enrolled? I've researched this a great deal but there is still a lot of risk. Key questions in my mind:

What value - if any - does ASN contribute?

Can they target good vs bad ASN vs just blasting all ASN clumps?

What are long term effects of eliminating ASN clumps?

Finally, the safety trial (phase 1) was small, short and saw no symptom improvement

Why would I do it? I am still early phase (as defined by this study) and it's a sure thing in terms of reducing ASN clumps which may be the only way to slow progression.

[rebtar]

No, i don't know anyone who is enrolled. If you have links to the research you've done i'd be interested.

[p-oui in reply to rebtar]

scienceofparkinsons.com/201.... I list a few more above

[jeffreyn]

This article from AlzForum discusses the recently-published PRX002 Phase 1b results.

alzforum.org/news/research-...

[jeffreyn in reply to jeffreyn]

This post on the SoPD blog covers the recently-released PRX002 Phase 1b results (and includes a lot of background information).

scienceofparkinsons.com/201...