This is a popular write-up on the GSK3 enzyme.
So far as I can tell, at autopsy, there are typically a variety of species of gunk present (a/sun, tau, etc.) —not just one—and correct diagnosis is associated with the most prevalent species.
My thinking (at the moment) is that genetics dictate which of the different species of gunk, but the dynamics of aggregation that drive progression are mostly the same.
So I follow anything in any of the neurodegenerative illnesses that seem to help and so far generally find what works in one, works in others.
Again, if asymptomatic people have our species in their brains at autopsy, then our symptoms can be significantly retarded as well.
The newsiest part of this article is that the infinitesimal mcg dose of Lithium stabilized Alzheimer’s patients with no further cognitive decline while the placebo group continued to deteriorate.
Lithium is a GSK3 inhibitor and an autophagy stimulant.
The ultra-low dose of Lithium (300mcg) is a tiny fraction of the bipolar dose, analogous to the amount in the drinking water in some places... where they have unusually low rates of suicide, homicide, violence, arrests, and depression.
It’s considered a “dementia preventative”
Lithium Orotate is a health food supplement.
Used in high doses for years with no known drug interactions and the ultra low dose does the job.
I like the “trace dose” meds because the risk/benefit is always zero to positive and it’s not enough to provoke a drug interaction.
For me, even with no miracle cure, if the progression were halted, I’d be a happy camper.