Growth factors are naturally occurring regulatory molecules, which bind to receptors on the cell surface. They stimulate cell and tissue function through influencing cell differentiation by changing their biochemical activity and cellular growth, and regulating their rate of proliferation.
Growth factors are quite versatile, stimulating cellular division in numerous different cell types; while others are specific to a particular cell-type.
Wikipedia states:
A growth factor is a naturally occurring substance capable of stimulating cellular growth,[1] proliferation,
healing, and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes.
So, if we could find out what causes our bodies to produce these growth factors, we can replace or repair damaged cells. In our case these are the dopamine producing cells in our brain and the Growth Factor is called GDNF (Glial Derived Neurotrophic Factor) and that repairs or replaces those cells and gives us more natural Dopamine.
Why are scientists not looking for natural ways of producing more GDNF in our brains to overcome Pd?
I think that Fast Walking does just that.
Written by
JohnPepper
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Thanks for the promotion, or was it sarcasm? I am not a doctor, just a patient who has had experience in successfully dealing with Pd and have no desire to make a business out of it. I want to find a CURE and I believe it to e possible.
"To get GDNF to the brain cells that need it, participants had 4 tubes carefully placed into their brains that were connected to a small port behind their ear. This device allowed GDNF to be passed directly through the tubes to the affected brain areas with pinpoint accuracy."
In my understanding John: This is a high risk procedure ; +With an extremely very high risk following on when a 'top up' is required... How does one ensure the inserted tubes will remain adequately sealed & sterile in between treatments!!!! ?
That said; one hopes that somewhere a scientist or two may be looking at better ways to get existing GDNF more activated.
How are you so sure your Fast walking is 'factually' & beyond doubt actually producing GDNF?
Is there a scientific way to find out levels of GDNF without a biopsy of brain tissues?
I am not knocking or mocking you; I would love a Cure like every sufferer and my questions are towards seeking a way forward via collective thought and joint effort.
John was not recommending any procedure like you referenced, but gave some information about GDNF, asked the question: "Why are scientists not looking for natural ways of producing more GDNF in our brains to overcome Pd?
" and made the statement: "I think that Fast Walking does just that."
Here is a link with information obout GDNF and includes 67+ ways to naturally increase GDNF (with references) mybiohack.com/blog/gdnf-wha...
Here is the copied list of Lifestyle factors that affect GDNF from the above site :
Lifestyle/Diet
Calorie Restriction (Ketogenic Diet) R
Exercise (like HIST) R R
Green Tea R
Intermittent Fasting R
Plantains R
Stress Reduction (GDNF is suppressed by stress) R
If you go to that siye and click on the R it takes you to the referenced study for that factor. Hope this helps..
Hi Andy. Because I did two years of high level exercise in the gym for 90 minutes six day a week and watched my Pd get progressively worse, and then stopped going to the gym and started doing fast walking, slowly building up from 20 minutes every second day to one hour every second day over a six month period reduced my symptoms quite noticeably. 4 years later nobody would ever have noticed that I had Pd.
Interesting observation John. I fast walk daily 45 - 60 but I also do other strenuous activities (not every day, maybe 4t/w) I have wondered if doing too much might not be helpful with progression. All I read about this is do more and more to reduce progression
My story gives you the answer to your question "If doing too much might not be helpful with progression?"
For the first two years, after diagnosis, I went to the gym every day for 90 minutes and watched my Pd get worse at a faster rate than it had before diagnosis.
When I started to walk fast for only 20 minutes every second day, increasing it by 5 minutes every second week until I was doing one hour, my symptoms started to get better!
After only 4 months of this regimen they showed strong signs of improvement.
After 4 years, nobody would ever know I still had Pd, other than a trained professional.
After another 4 years I was able to come off all Pd medication and have been medication-free since 2002.
The medical opinion is that if you fatigue the mitochondria (PD involves mitochondrial dysfunction) it contributes to the progression of neurodegeneration.
Exercise promotes many beneficial biological processes. You need to find the balance between promoting the positive effects and minimizing damage from over exertion.
I was diagnosed with Parkinsonism with tremors now changed to motor neuron disease. Overworking muscles causes the neurons to die faster.
GDNF cannot pass the Blood Brain Barrier (BBB) therefore we cannot successfully take GDNF orally.
My point is that the very name GDNF tells us that it is produced naturally in the brain itself. Therefore, why do we not spend our BUCKS on finding ways to produce more GDNF naturally?
Yes. I am about 40 days into a micro dose regimen of approximately 20mg twice a day together with a B vitamin complex. The results are quite encouraging. I have posted them elsewhere on this site if you are interested.
I have read through all that information and not being able to understand most of it, I came out with the following impressions:
Ibogaine is intended for drug addicts and drunks, and I am not not either of those .
Ibogaine has serious side effects: Despite its attractive properties, Ibogaine can induce severe side-effects such as hallucinations, whole-body tremors and ataxia that may be related to neurotoxicity in the cerebellum and dysregulation of the cardiovascular system
I therefore repeat my question: Have any studies been done on the use of Ibogaine?
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Dr. Simon Stott's recording is now available- PD research round up 2021 & looking ahead to 2022
