Acetylglutathione - updated - questio... - Parkinson's Movement

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Acetylglutathione - updated - questionable

park_bear
park_bear

Update - It appears some of the key references for this article do not support its contentions. It should therefore be disregarded. The good reports at Amazon are good as far as they go but carry lesser weight. See instead the comment and research by Greenday posted below.

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clinicaleducation.org/resou...

"Acetylglutathione is orally active, unlike plain glutathione, and is stable in the intestine and plasma when absorbed and delivered directly to the cells for natural de-acetylation intracellularly. Plain glutathione delivered to the plasma by precursors, liposomal products or intravenously must be broken down by enzymes to the basic amino acid components for absorption into the cell and require more energy expenditure to be re-constructed back to rGSH. It is known that disease states can block the re-assimilation of components into rGSH. Therefore, it is a better dietary/therapeutic decision to provide the orally active and absorbed Acetylglutathione which increases intracellular rGSH directly and naturally without increased energy expenditure and without being compromised from disease states.[7],[8]"

Some good reports on this version:

amazon.com/Glutathione-Acid...

16 Replies
oldestnewest

Very interesting!!

And which dosis / day and preferably which form >> tablets , powder ? With drink // meal. before //after ??

And do you, park_bear use Mucuna ??

park_bear
park_bear in reply to JANVAN

I do not use Mucuna. Here is best deal I found: amazon.com/gp/product/B01AJ...

Plan on taking 2x/day. Don't know with regard to meals.

Pls keep us all posted on yr findings and if this makes you feel better

I have been thinking of trying Liposomal Glutathione. It was recommended as being the most bioavailable form, but now I am curious which would be better.

Liposomal has better evidence - see update above.

Park bear,

I am still unclear of the difference between S-Acetyl Glutathione and Liposomal Glutathione, or is it the same?

They are different - liposomes explained here: en.wikipedia.org/wiki/Liposome

Whereas S-Acetyl Glutathione has an acetyl group tacked on to its sulfur atom allegedly allowing it to get absorbed intact.

My ND has recommended liposomal glutathione.

Been taking that brand for 2 years 2/day with liposomal C and 5k iu D/k2 in the AM as suggested by functional medicine practioner.

Is there any published human study with acetylglutathione in pubmed or any other scientific journal? I can only find a few cell/animal studies.

Liposomal glutathione and NAC have a proven record of efficacy in multiple human studies:

“Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function.“ ncbi.nlm.nih.gov/pubmed/288...

“Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress.” ncbi.nlm.nih.gov/pmc/articl...

However Oral Glutathione or NAC alone may not be as effective as IV administration to increase glutathione levels in the brain.

Intranasal glutathione might be able to increase gluathione in the brain but more studies are needed as the placebo effect was overwhelming in a recent human study ncbi.nlm.nih.gov/pmc/articl...

Another study suggests that sublingual gluathione is superior to oral glutathione: “Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study.“ ncbi.nlm.nih.gov/pmc/articl...

Possibly Glutathione nanoliposomes <150nm may readily cross the blood brain barrier (BBB) and cell membranes. However most commercial glutathione liposomes are over 200nm. ncbi.nlm.nih.gov/pmc/articl...

park_bear
park_bear in reply to Greenday

First, thank you so much for this good research.

Second, I was taking the authors' word on this piece that I posted and it is now apparent that I should not have. I could not find any references either. Moreover, their claim: "The most significant marker, considered a gold standard, was F2-isoprostane and this was significantly more reduced by oral Acetylglutathione than with the IV glutathione.[11],[12]" is not supported by the references given. In fact, neither reference even mentions acetylglutathione. Lesson learned and thanks again. Will update my post accordingly.

Seems like sublingual might be the way to go. Came across this...any thoughts?

amazon.com/CCL-Glutathione-...

Need to research a bit further.

came across this review FWIW: amazon.com/gp/customer-revi...

Doing some research and came across Protandim and IV injections of glutathione. Pretty remarkable results.

Anybody here tried this product or had injections?

youtu.be/KWuOezgVHdI

I knew someone who tried IV glutathione and although it was somewhat effective, it was VERY expensive and inconvenient. Not many people can do IV at home. Laurie Mischley was not (when I saw her 2011-2012) a proponent of it. She felt that the majority of it would go to lungs and other parts of the body before the brain.

The videos from Dr. Perlmutter are fairly old and he has not done any type of trials with it (that I know of).

Greenday
Greenday in reply to Juliegrace

IV injections with nanoliposomes may readily penetrate the brain barrier. The technology exists with some drugs, but I've yet to see any application with glutathione alone.

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier. ncbi.nlm.nih.gov/pmc/articl...

In theory, long term IV administration or the oral administration of a biovailable form may able to penetrate the brain barrier though slow difussion but no studies exist to verify this approach.

Glutathione administration may benefit those with deficiency. There are blood/plasma exams that can show the levels of GSH and GSH to oxidized ratio (GSH/GSSH)

The Perlmutter D. study is the following

Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease.

ncbi.nlm.nih.gov/pubmed/192...

"There were no significant differences in changes in Unified Parkinson's Disease Rating Scale (UPDRS) scores".

"Over the 4 weeks of study medication administration, UPDRS ADL + motor scores improved by a mean of 2.8 units more in the glutathione group (P = 0.32), and over the subsequent 8 weeks worsened by a mean of 3.5 units more in the glutathione group (P = 0.54). "

Glutathione was well tolerated and no safety concerns were identified. Preliminary efficacy data suggest the possibility of a mild symptomatic effect, but this remains to be evaluated in a larger study."