Hi all. I discovered this page a few days ago and find that participants are very knowledgeable. I am wondering if anyone knows if idiopathic PD symptoms give clues as to how one’s dopamine system is affected. I think I understand that you may simply have ran out of your life supply of dopamine, or that dopamine pathways are damaged, or that your PD originated from a gut infection, or many more that I can’t understand when reading studies.
I was diagnosed 7 months ago with idiopathic PD (female, age 55). Symptoms started 1½ yr prior to diagnosis and are all on the left side: some tremors with movements (few), no resting tremors at all. Shoulder, arm, fingers, leg, foot and toes are very stiff and weak (probably lost about 75% of all movements). I drag my leg when I walk more than a few seconds. My tongue is slightly rigid, I often have double vision, I act out my dreams (hit my spouse without intention, scream, etc.) without waking up.
I took Sinemet for one month upon diagnosis. The neuro said it would confirm the diagnosis. It turned out detrimental to me. After a few days, my left hand became a lot stiffer (anyone know why PD medicine would cause PD symptoms?). Every morning, it was worse than the day before and when I stopped taking it, my hand was less stiff every morning… but never made it back as it was prior Sinemet. I also felt a huge agitation/anxiety state that stopped entirely a few days after I stopped Sinement. After one month, I had about 10% improvement on walking, no other benefit. The neuro held on his PD diagnosis even though Sinemet didn’t work.
He then put me on Mirapex which sent me to the ER with arrhythmia after about 4 days… Since there is cardiac disease in my family, I was told to stop Mirapex. Also on Mirapex, I had resting tremors for hours right after taking a dose…(another pd med causing pd symptoms…).
I then took Amantadine for 3 months which improved movement, including walking, by about 25%, as long as I did 1 to 2 hrs exercises a day, every day. The side effects were so bad that I stopped : sleeping no longer than 3 hrs a night, lost appetite/weight, incredible constipation, facial tics that were very embarrassing at work, and augmented movement tremors. All side effects ended within a few days after stopping the medication, so did the benefits. Right now, I can’t exercise more than a few minutes; I am fighting against ‘’concrete’’ stiffness and I become shaky.
The neuro told me to go back on Sinement. I asked a second and a third opinion on his prescribing Sinement and on his diagnosis, and they all said the same. The three of them are movement disorder neurologists so I guess they are right about the diagnostic.
However, I will not take Sinamet again. I am now reading about natural medication but I want to treat the area of my dopamine system that is defective. Any thoughts? Many thanks.