The key to ketosis and neuroprotection? NAD+???

[sunvox]

Disclaimer: NEVER EVER try something based on some comments from the internet. ALWAYS talk to you doctor before trying something new.

So I LOVE how much sharing of information goes on here, and I love even more how what I learn keeps pointing me in new directions where I find new information. Anyways, not everyone may find this as interesting as I do because admittedly I am already sold on the benefits of Niagen, but here's what happened this morning.

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First, one member chimed in on another discussion and mentioned her positive experience with a keto diet helping her control her PD progression. I had read mixed reviews on the neuroprotective benefits on ketosis previously so I was intrigued to revisit the topic. (I should mention I tried a keto diet myself for awhile but I wasn't doing it for neuroprotection.) Anyways, first I hit these articles:

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Neuroprotective and disease-modifying effects of the ketogenic diet

ncbi.nlm.nih.gov/pmc/articl...

Treatment of Parkinson disease with diet-induced hyperketonemia: a feasibility study.

ncbi.nlm.nih.gov/pubmed/157...

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BUT - then it got really interesting to me because that led me to this very recent study done only last year:

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Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism?

ncbi.nlm.nih.gov/pmc/articl...

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The full study is free to read, but essentially the researchers found evidence that the reason a ketone diet may help is because it increases production of NAD+. Now if you read any of my other posts on the ataxia forum and here, you will quickly learn that I am a HUGE fan of Niagen because Niagen is a new form of vitamin B3 that does not have the dangerous side effects that other forms of B3 have, and it's a proven MEGA-booster of NAD+.

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One of the major symptoms I used to have was stiffness in my legs. I have been a runner since age 14, but in the last couple of years I was running slower and slower and no matter how much I stretched, my legs always felt heavy and stiff, that was until I started taking 1000 mg a day of Niagen. I got banned from here last year because I came on a little too strong, but I can not say enough good things about Niagen. I REALLY wish everyone here would talk to their GP and then try 1000 mg a day for a month just to see for themselves. Niagen is a little expensive, but I believe it is the single best supplement to aide in neuroprotection. What's crazy though is that the role of NAD+ was first hinted at way back in 1993!

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Niagen

Nicotinamide adenine dinucleotide (NADH)--a new therapeutic approach to Parkinson's disease. Comparison of oral and parenteral application (the study from 1993)

ncbi.nlm.nih.gov/pubmed/810...

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and then over 2 decades later:

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Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease

ncbi.nlm.nih.gov/pmc/articl...

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

nature.com/articles/s41514-...

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

researchgate.net/publicatio...

sciencedirect.com/science/a...

ncbi.nlm.nih.gov/pmc/articl...

cell.com/cell-metabolism/fu...

cell.com/cell-metabolism/fu...

ncbi.nlm.nih.gov/pmc/articl...

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Anyways, like I said I'm already sold on Niagen so maybe I found this more interesting than most

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Joe

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P.S. For the record I have NO connection what so ever to the makers of Niagen. I'm just a REALLY strong believer in this product.

EDIT: I should add that I have been taking 1000 mg a day for nearly a year. I have played around and backed off to 250 and 500 a couple times, but ultimately I came back to 1000 mg a day for myself.

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Also, there are numerous clinical trials at that level:

clinicaltrials.gov/ct2/resu...

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truniagen.com/

[parkie13]

Seems to me like there's more and more evidence, all the time, for the efficacy of B vitamins. That is very interesting.

[JANVAN]

Very interesting !! Thank you very much, I will try it , together with Vit B1 from

Dokter Costantini.

VGr., Jan.

[kaleiann in reply to JANVAN]

did you actually try both together and if so Please share any positive or negative results and your dosages ?? THANKS so much!

[wifeofparky]

My husband took B Complex supplements. We noticed a difference if he missed a few days. The b's work together so taking all of them is better than isolating on one or two.

And ALWAYS discuss this with your MDS before you try anything. You do not want a bad reaction

[Astra7]

Interesting. I read an article yesterday about the benefits of fasting. My legs are heavy as well and I'm slowing down on the tennis court.

It can be frustrating when you find something that works for you and other people are hesitant to try it! Ie my old favourite NAC.

I'll add some to my supplements regime. I don't bother asking the medicos as they don't seem interested in much!

[memegl]

us

[John112233]

I just posted this to another thread will repost here

Niacin B3 is low in Parkinsons too. B3 makes NADH

ncbi.nlm.nih.gov/pmc/articl...

Edit: Oops linked the wrong study will try found the other one.

Looks like it is a multi b vitamin deficiency disease. Nutritiondata is a good website with the nutrient content of different foods. One can type in a food or search a specific nutrient (tools- nutrient search tools). Good sources of b vitamins I have found are -Rice bran (also high mineral content) , the different yeasts (bakers, brewers, nutritional- don't recall mineral content), mixed nuts (also high mineral content) . A big bowl of rice bran cereal, and one cup of mixed nuts a day will provide the RDA for most b vits, and nutrients, and for some of them will provide well over the RDA. List of essential nutrients effectscausedbylackofessent...

[SilentEchoes]

Makes sense to me. Thamks for sharing.

[karlschmo]

Thanks for posting this library of articles Joe, I appreciate you taking the time to compile them. The evidence is pretty compelling.

I'm curious, are you supplementing with pterostilbene as well, per the Nature article?

[AmyLindy]

Joe, Love ur references- as always!