Simple molecule could prevent diabetes 2 ------- coenzyme Q10

[parkie13]

sciencedaily.com/releases/2...

[11_dentist]

I saw the article about Q10

Asked an a diabetic specialist in Australia. Said great research

But liquid form in mice might help

Q10 capsules won't help humans

Is the best advice available.

[parkie13 in reply to 11_dentist]

I know, I read that too, that the bioavailability of coenzyme Q10 is very limited. I read couple posts by Silvestrov and I was surprised that he is having good results with it, in Parkinson supplementation. I do have diabetes 2 and I am on insulin, I couldn't take Metformin. And I wanted something with as few side effects as possible.

[11_dentist in reply to parkie13]

In a rash move recently I was persuaded by a local and most enthusiast pharmacist known in the UK as the most vocal Q10 advocatea a large number of Q10 capsules in an attempt to help some muscle loss. I suppose even if limited absorption it can't do any harm.

I wish you all the best in your double diagnosis.

[silvestrov]

I wish I would have know you had diabetes because there is a herb which is both good for any form of diabetes and PD: Trigonella foenum graecum (Fenugreek).

Efficacy and safety of standardized extract of Trigonella foenum-graecum L seeds as an adjuvant to L-Dopa in the management of patients with Parkinson

forum.parkinson.org/topic/1...

Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes.

ncbi.nlm.nih.gov/pubmed/219...

Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study.

ncbi.nlm.nih.gov/pubmed/118...

As for having CoQ10 help my health it is really the combination of CoQ10 and high potency fish oil. Years ago when I started to take 1,200 mg of standard CoQ10 I was already taking a high potency fish oil supplement containing 500 mg of DHA omega 3. Quite recently I ran out of fish oil and in a nonchalant manner I said I would get it sometime. About a week to 10 days later I started to feel unwell and had pain in my chest and thought my fasciculations were returning. Years ago, after I started taking dopamine-producing supplement to relieve chest tremors, stiffness, depression, etc... I noticed my chest had fasciculations/muscle twitching. After taking CoQ10 (in combination with DHA/fish oil) the fasciculations went away.

This therapeutic outcome made me think about the cause of PD and PD testing with herbicides, pesticides, fertilizers, etc... Clinical testing of CoQ10 uses a chemical model of PD featuring rotenone, MPTP, maneb, paraquat, etc.... and CoQ10 relieves chemically-induced symptoms.

MPTP PD mice model:

Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of Parkinsonism

onlinelibrary.wiley.com/doi...

Rotenone PD model:

Water-Soluble Coenzyme Q10 Reduces Rotenone-Induced Mitochondrial Fission

link.springer.com/article/1...

Neuroprotective effects of coenzyme Q10 on paraquat-induced Parkinson's disease in experimental animals

readbyqxmd.com/read/2890267...

You mentioned that CoQ10 is not well absorbed and most of it is fat soluble - meaning, fat must be consumed with the supplement. Hence one of the reasons why my combination of coq10 and fish oil works. I take them together 3 times a day.

In the above study they use a water soluble form of CoQ10 and if you want to maximize the efficiency of this supplement, water soluble is best.

And finally, my experience with the effectiveness of CoQ10/fish oil on treating my chemically-induced pre-parkinsonian syndrome made me think that perhaps chemicals (used in PD testing) were a contributory factor to PD and not its cause.

2 of the above test uses use rodents and consider the following. There are 2 bacterial-induced rodent models of PD:

Nocardia otitidiscaviarum (GAM-5) induces parkinsonian-like alterations in mouse

scielo.br/scielo.php?script...

Movement disorders in encephalitis induced by Rhodococcus aurantiacus infection relieved by the administration of L-dopa and anti-T-cell antibodies

onlinelibrary.wiley.com/doi...

Nocardia otitidiscaviarum and Rhodococcus aurantiacus are bacteria closely related to Mycobacterium tuberculosis because they are bacteria with fungal attributes. Myco means fungal and both Nocardia and Rhodococcus were once thought to be fungi. Only within the last 25 years they were actually discovered to be bacteria.

In my documentary I went on and on about bacteria as a possible cause of PD and I thought the following: In either of the above mouse models of PD (that were induced by bacteria), what effect, if any, would coenzyme Q10 supplementation have on a bacterial infection?

Hence my hypothesis as to why CoQ10 has (generally) poor and inconsistent results in actual PD patients.

[parkie13 in reply to silvestrov]

Thank you for taking time to answer. How do you know which supplement of coenzyme Q10 is fat or water soluble? It will take me awhile to go through all those. Thank you again Mary

[silvestrov]

Mary,

Here is a 'water soluble coq10' search on amazon.com and it lists various brands (try ebay also):

amazon.com/water-soluble-co...

If not listed as water soluble Coq10 is fat soluble and hence standard Coq10. The concerns of absorbing fat soluble coq10 as a cancer therapy was expressed in the following article:

"Dr. Judy suggests a way to improve the absorption of CoQ10 capsules into the blood stream. Put the capsules of CoQ10 in hot tea which melts them. CoQ10 needs fat to get improved absorption. Add a teaspoon of coconut oil preferably but butter will also work. Drink the tea warm or hot."

newswithviews.com/Howenstin...

Coconut oil and CoQ10 in tea for PD, hmmm.....

[parkie13 in reply to silvestrov]

Thank you