How much is "high" dose?

[moonsake10]

My doctor elevate my sinemet from 2 to 3 , 10-100 mg every 3 hours and pharmacy said that was high. What say ye?

[Bailey_Texas]

Don't know what high is i take 2 25/100 and 1 50/200 ext re every 4 hours 24/7 and 2 6 mg requip once a day.

[CplParkinson in reply to Bailey_Texas]

Wow, before DBS I was up to 2-25/100mg tablets every 2 hours 1-100mg amantadine every 3 hours 4x a day. 2-50/200mg tabs at night to sleep. Now 1 1/2 -25/100 every 4 hours

[andrewij]

I'm not sure that is a high dose. How long have you been diagnosed?

I take 5x25/100, and 5x25/100 CR, 1mg Rasagaline, per day. I have been diagnosed 12yrs 3months,

[M_rosew]

Not qualified to comment on amount, BUT the leaflet with my Sinemet CR says they should not be taken at intervals of less than four hours.

[Hidden]

2,000mg/day

Doc. Stanley Fahn

World-famous leader in movement disorders, Dr. Stanley Fahn was the keynote speaker discussing myths and misconceptions in PD, and several members of the University of Florida Center for Movement Disorders and Neurorestoration also spoke and participated.

video

youtu.be/utVZaOLUiDo(Not working as expected?)

37:20

his top limit 2,000mg/day

[moonsake10 in reply to Hidden]

Is the last number of 10-100 how you arrive at total mg?

[Hidden in reply to moonsake10]

10mg carbidopa, 100mg levadopa

[Bailey_Texas]

i take 2400 mg a day and have taken 3000

[jdc3]

I take 25-100 (Madopar) along with100mg of Comtan 2 or 3 or 4 times per day, usually another 100mg time-released at bedtime It seems like when I take the drugs it take, 45 minutes-1hour to get some relief which then lasts from 90 minuets - 135 minutes. So, if I wanted to be "On" all the time I would have to take them every 2 hours.

I have no Doctor so I've done a lot of internet researching, and it makes my head spin. Some Doctors say take as little as possible, others say 2000 mg/day is OK. Still others say it's very dangerous to modify your dosage frequently - in fact it can be very dangerous to even get of your schedule by an hour or so. It's all so very confusing.

You would think that a drug which has been given to millions of people for 60 years would be better understood!

[Juliegrace in reply to jdc3]

I modify my dosage and change the times I take them daily according to how much sleep I get, what I have to do that particular day and how much dyskinesia I have. The only PD med I take is 10/100 carbidopa/levodopa.

[Maja54]

Hi moonsake I had PD for 12 years now. I do not think you are at your max yet I take carbo/levodopa 25/100 2tab q 3 hr 7x a day. that dos not hold me , only for about 1 hr. the rest I was very tight and very uncomfortable. My Nero added Endocapone , that helps.My off times are not is painful .

[Maja54]

Hi moonsake you count the mg in Levodopa which is the drug making you feel better carbidopa is enhancer . So the levodopa is 100 mg you calculate depends haw many u take. That can be up to 2000 mg.

[moonsake10]

Thank you