(Longecity does have a lot of good researchers.)
Notice, there is a lot of overlap. Even if I could afford all this stuff, my stomach's not big enough to hold it all.
"The purpose of this stack is to possibly:
induce mitochondrial biogenisis ( PQQ, Nicotinamide Riboside )
prohibit a-synuclein aggregation ( PQQ, NAC, Bacopa monnieri, EGCG, flavonoids: Nobiletin, Apigenin, Fisetin )
increase / sustain dopamine levels ( Citicoline, NAC, Mucuna Pruriens, Bacopa Monieri )
increase glutathione levels in mitochondria (NAC)
offer neuroprotection ( PQQ, NAC, Ubiquinol Q10, EGCG, Curucumin solid lipid / micellar, Lipoic Acid, Oleuropein, Taurine, Acetyl-Carnitine, Anthocyanins, Bacopa monnieri, Vitamin D3, L-Theanine, Omega-3, flavonoids: Apigenin, Nobiletin, Fisetin, Genistein )
exhibit anti-inflammatory activity ( Curucumin solid lipid / micellar, Omega-3, NAC, Flavonoids, Anthocyanins, Oleuropein, NAC )
offer overall antioxidant protection. ( Ubiquinol Q10, PQQ, NAC, Flavonoids, Anthocyanins, Lipoic Acid, EGCG, Vitamin C with bioflavonoids )
lower homocystein levels ( Folate, B12, NAC )
Improve mitochondria function & energy ( Nicotinamide Riboside, PQQ, Ubiquinol Q10, NAC, Taurine, Acetyl-Carnitine, Omega-3, Phosphatidylserine )
Recommended Physical Exercise to improve balance and motor control :
Tai Chi & Qigong
Tai Chi and Postural Stability in Patients with Parkinson's Disease (N Engl J Med, 2012)
Effects of Tai Chi on balance and fall prevention in Parkinson's disease: a randomized controlled trial. (Clin Rehabil. 2014 )
A Meta-Analysis on the Efficacy of Tai Chi in Patients with Parkinson's Disease between 2008 and 2014
Effects of Health Qigong Exercises on Relieving Symptoms of Parkinson's Disease.(2016)
1) Ubiquinol CoQ10
Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson's disease. (Parkinsonism Relat Disord. 2015 )
Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum (Barca E1, Kleiner G1, 2016)
2) PQQ Pyrroloquinoline Quinone (BioPQQ)
Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions (Adv Exp Med Biol., 2016)
Neuroprotective effects of pyrroloquinoline quinone against rotenone injury in primary cultured midbrain neurons and in a rat model of Parkinson's disease (Neuropharmacology, 2016)
Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression
3) Acetyl Carnitine + Lipoic Acid
Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease. (J Cell Mol Med., 2010)
4) NAC (N-acetyl-cysteine )
Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice (PLoS One. 2010)
N-Acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases. (Clin Neuropharmacol. 2013)
5) Omega 3 Fatty Acids
Neuroprotective effect of omega-3 polyunsaturated fatty acids in the 6-OHDA model of Parkinson's disease is mediated by a reduction of inducible nitric oxide synthase. (Nutr Neurosci, 2017)
Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA (Front Aging Neurosci. 2015)
6) Green Tea (EGCG)
Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties (Genes Nutr. 2009)
Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease. (Brain Res. 2014)
8) Citicoline (CDP-Choline)
Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair. (Rev Neurol Dis. 2008)
Citicoline in the treatment of Parkinson's disease.
9) Solid Lipid Curcumin
Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations. (J Med Food. 2015)
Reduced plasma taurine level in Parkinson's disease: association with motor severity and levodopa treatment.
Mechanism of neuroprotective function of taurine. (Adv Exp Med Biol, 2009)
11) Folate, B12
Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study. (Zhang S1, 2015)
Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study.
High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: no role for serum level of homocysteine.
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease (Cell. 2016)
Use of probiotics for the treatment of constipation in Parkinson's disease patients.
The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies (Eur J Pharmacol. 2017)
13) Milk Thistle (silymarin)
Silibinin prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease via mitochondrial stabilization.
The neuroprotective effect of fisetin in the MPTP model of Parkinson's disease. (J Parkinsons Dis. 2012)
Curcumin and Apigenin – novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease (Neural Regen Res. 2015)
Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.
16) Nicotinamide Riboside (NR) (NAD+ precursor)
Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease (Biol Open. 2017)
Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age-related disorders (Clin Transl Med. 2016)
17) Nobiletin & Tangeretin
Nobiletin protects dopaminergic neurons in the 1-methyl-4-phenylpyridinium-treated rat model of Parkinson's disease. (J Med Food. 2015)
Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease.
18) Bacopa monnieri
Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease.(Biochem Biophys Res Commun. 2011)
l-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes
20) Vitamin D
Serum vitamin D and the risk of Parkinson disease.
Systematic Review of the Relationship between Vitamin D and Parkinson’s Disease (J Parkinsons Dis. 2016)
21) Phosphatidylserine (PS)
Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT).
22) Olive Oil & Oleuropein
Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model (Int. J. Mol. Sci. 2016)
23) Mucuna Pruriens
Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study. (J Neurol Neurosurg Psychiatry. 2004)
An alternative medicine treatment for Parkinson's disease: results of a multicenter clinical trial. HP-200 in Parkinson's Disease Study Group. (J Altern Complement Med. 1995)
24) Magnesium L-threonate
Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial (J Alzheimers Dis. 2016)
Ubiquinol CoQ10100 mgtwice daily1 Softgel morning with breakfast / 1 softgel evening with dinner
PQQ Pyrroloquinoline Quinone (BioPQQ)10-15 mgevery other day1 softgel morning with CoQ10
Omega-3 DHA + EPA (3:2)350-550 mgtwice daily1 Softgel morning with breakfast / 1 softgel evening with dinner
N-Acetyl Cysteine (NAC)900 mgevery other day900mg effervescent dissolved in water or 600mg capsule/tablet with fruit juice
Acetyl Carnitine (ALCAR)500 mgDaily1 capsule/powder Between meals
CDP Choline (citicoline)300 mgDaily1 capsule with lunch / possible to replace with Uridine but more research is needed)
Solid Lipid Curcumin400 mgDaily1 softgel preferably with food
Phosphatidylserine (PS)100 mgDaily1 capsule with a meal
EGCG (green tea catechins)250 mgevery other day1 capsule/tablet with a meal
L-Theanine (black & green tea)100 mgevery other day1 tablet/capsule in the afternoon
Milk Thistle (silymarin)250 mgevery other day1 tablet/capsule with dinner
Vitamin B12 Methylcobalamin25 µgDaily1 capsule/tablet with breakfast
Folate (L-methylfolate)400 µgDaily1 capsule/tablet with breakfast
Vitamin D3 (Cholecalciferol)1000 IUDaily1 softgel with breakfast
Nobiletin & Tangeretin (citrus flavonoids)100 mgevery other day1 capsule (currently found as sytrinol proprietary blend)
Blueberry Extract (anthocyanins)500 mgDaily1 softgel
Lipoic Acid50-100 mgDaily1 capsule/tablet with food (may increase effectiveness of ALCAR if taken together)
Bacopa monnieri (50% bacosides)300 mgDaily1 capsule with a meal
Taurine500 mgevery other day1 capsule between meals.
Olive Oil Fruit & Leaf (Oleuropein) Extract500-1000 mgDaily1 capsule/softgel
Raw Fruits & Vegetables5 serving(s)Dailypreferably organic / also include nuts like Walnuts Macadamias rich in omega 3
Nicotinamide Riboside (NR) Niagen125-250 mgevery other day1 capsule in the morning
Vitamin C with Citrus Bioflavonoids500 mgevery other day1 capsule with food
Apigenin (bioflavonoid)50-100 mgevery other day1 capsule with food
Fisetin (flavonoid)50-100 mgevery other day1 capsule with food
Probiotic complex1 pill(s)Daily1 capsule in the morning
Magnesium L-threonate48 mgDaily1 capsule with dinner"