Parkinson's Movement

Gut Microbiota Dysfunction - Early Diagnostic Biomarkers in PD

Gut Microbiota Dysfunction as Reliable Non-invasive Early Diagnostic Biomarkers in the Pathophysiology of Parkinson's Disease: A Critical Review.

J Neurogastroenterol Motil 2018 Jan 30;24(1):30-42.

ncbi.nlm.nih.gov/pubmed/292...

ncbi.nlm.nih.gov/pmc/articl...

[open access].

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How do we repair the gut and restore our Microbiota to a healthy state? Can this even be accomplished? I'M now in my 60's and time is running out. I have had dysbiosis since my mid teens after I was given several different broad spectrum antibiotics by a dermatologist. My gut was carpet bombed and I never was healthy as a result. Have tried fecal flora implant on my own which was not successful though I still believe that is probably the only hope I have to heal my gut.

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I do not think there is a quick way for those suffering from PD unless the specific deficiency or rogue element can be identified, and that in its self has always coloured my thinking as I continue to search for a Natural Remedy.

A few years ago (as documented in this forum) I trialed particular plant extracts that had initially proven to make me feel in a state of repair. However, the 'BocowoA recipe' failed to deliver in replicating the effects 2nd time round and I put the initial results down to 'the brisk walking exercise' it had enabled.

I am currently trialing another plant extract (along side one utilized in the BocowoA trial) and if the results start to show proven benefits & promise, I will try to obtain more scientific data (if I can find a biochemist interested in assisting) and then get it into the marketplace in due course.

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Abnormal colonic endocrine cells in patients with chronic idiopathic slow-transit constipation.

Scand J Gastroenterol 1999 Oct;34(10):1007-11.

ncbi.nlm.nih.gov/pubmed/105...

The changes in colonic endocrine cells in patients with slow-transit constipation may be one cause of the decreased motility in the colon and consequent development of constipation.

Mucosal serotonin signaling is altered in chronic constipation but not in opiate-induced constipation.

Am J Gastroenterol 2010 May;105(5):1173-80.

ncbi.nlm.nih.gov/pubmed/200...

Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility.

Sci Rep 2017 Mar 27;7(1):441.

ncbi.nlm.nih.gov/pubmed/283...

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What clues have I obtained from the recently posted gastrointestinal citations?

Background: My parents were adolescents as the Depression began in 1929. During my childhood and beyond, the family would save leftovers too long, stews wre used too long (left-overs added for days. Only in ~2000 did I learn about studies documenting rate of increased counts of pathogenic bacteria by such habits in the kitchen.

Needless to say, the family had chronic bowel issues.

As a child, I had numerous rounds of antibiotics, mostly for otitis.

Many exposures to chemicals in my early, teens, twenties, thirties.

In my early 60s, leg cramps, slow fecal transit before lacunar infarct (2010), then PD dx (2011). My physiology was consistent with metabolic syndrome during 2004-2010.

After the lacunar infarct (Aug 2010), I experienced major weight loss, along with dysregulation of energy and appetite.

When I was 10 or 11, a dentist noticed mildly slow clotting and prescribed vitamin K1. To this day, I keep K1 and occasionally take one (when my body tells me to).

The recently posted GI studies are instructive (not conclusive).

Infection and aSyn. GI serotonin and impaired clotting. Hypersensitivity to some grains?

SIBO and mild malnutrition? Mg deficiency and early cramps in legs?

Appetite signals disrupted and energy tweaks by 5HT deregulation in gut. Constipation and GI serotonin.

That's all for now.

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Have you read this article? Maybe it's been posted on Healthunlocked? If not, feel free to pot it if you think it is important and helpful info.Thanks

sciencedirect.com/science/a...

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See also; Each is open access:

The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies.

[excellent review].

ncbi.nlm.nih.gov/pubmed/285...

Gut Microbiota Dysfunction as Reliable Non-invasive Early Diagnostic Biomarkers in the Pathophysiology of Parkinson's Disease: A Critical Review.

ncbi.nlm.nih.gov/pubmed/292...

Gut dysfunction in Parkinson's disease.

ncbi.nlm.nih.gov/pubmed/274...

Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson's Disease.

ncbi.nlm.nih.gov/pubmed/292...

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