I have just started to take it along with the sinemet (9 daily). Wondering if I should take it at the same time or at a different time? My doctor said it should not matter. I am not up to the full dose yet, but will be taking 3 a day. Any tips? It is too early to know for sure, but so far I am feeling less pain, stiffness and dyskinesia. But, I am experiencing more abrupt ons/offs. I am YOPD and was diagnosed 3 years ago, although like everyone, I think I have had it a long time. Thanks!