Encouraging stem cell info & trial for Parkinson's.

[MBAnderson]

Recently, there have been some discouraging posts, one for myself just yesterday, regarding stem cell therapy for Parkinson's. Here is some encouraging information.

This link is a one hour, but very interesting, video interview of a doctor explaining many of the applications of mesenchymal stem cells.

youtu.be/OtL1fEEtLaA(Not working as expected?)

From November, 2017. This review article describes the historical development of cell therapy for PD, the current status of cell therapy, and the future direction of this treatment method.

ncbi.nlm.nih.gov/pmc/articl...

There is a clinical trial through the University of Texas that is currently recruiting. Could be worth participating ...

clinicaltrials.gov/ct2/show...

ncbi.nlm.nih.gov/pmc/articl...

[Hidden]

The doctor extracted stem cells from my wife's blood. He injected her knees and now very little pain.

[MBAnderson in reply to Hidden]

You have a highly advanced Dr. you/she are lucky.

[PDConscience]

The problem with MSCs, or mesenchymal (adult/multipotent) stem cells, is that they're incapable of differentiating into the DA neurons that those of us with PD need to replace what we've lost. We need Yamanaka's IPSCs (induced/pluripotent) stem cells to accomplish that particular feat. Note the absence of any mention of neurodegenerative conditions/neurons in your "Clinical Applications of Mesenchymal Stem Cell" link: "In the clinical setting, MSCs are being explored in trials of various conditions, including orthopedic injuries, graft versus host disease following bone marrow transplantation, cardiovascular diseases, autoimmune diseases, and liver diseases."

The best that can be hoped for in the U of Texas trial is some anti-inflammatory effect. There are a couple labs working with IPSCs for PD but have yet to get FDA approval to proceed with human trials (mouse/primate trials succeeded in reversing the disease)...

[MBAnderson]

Boo-hoo. I knew the clinical applications link didn't mention neurodegeneration, but I included it because I thought it interesting. I did beleave the Texas trials held out some hope though. PD, what are your views on and Ambroxol?