Hi there. I'm Mary Jo. So glad to find this group. I'm already excited to try some new things you have all mentioned in your posts. I posted my big story in my profile if anyone wants all the usual PD details. The short version is I'm 62, live in Kansas, diagnosed 8 years ago, although symptoms began in 2008. I'm high functioning, live alone, and don't look like there's a thing wrong with me. Meds: Sinemet 6 tabs/day every 2/1/2 hours waking hours, which has proven to work the best for me. Also on Exelon patch and Amantadine. About a month ago I added Mannitol with some pretty good improvements in cognition, attitude, my voice, constipation, a few fine motor issues, that have really felt like huge baby steps of hope! (Although it has not impacted the tremors at all... Guess it can't be asked to do EVERYTHING!) Curious to test out the Thiamine after I've given the Mannitol a bit of time. Thanks for having this group!