Side effects of PD medicines

[Farooqji]

Prolonged exposure to dopamine replacement drugs can lead to dyskinesia, causing involuntary jerking and spasms of the whole body.

scotsman.com/news/health/sc...

[Tiger101]

My husband just diagnose about 3 months now has titrated to 36mg 2 tabs 3 x per day 6 total a day. He has not been on it very long but I am seeing twitching in his shoulders and constant moving in his toes but only when he does certain things like sitting in a particular chair. Could this be dyskinesia already?

[park_bear in reply to Tiger101]

Yes that is dyskinesia. Dyskinesia can happen at any stage if someone gets too much levodopa. His dosage is too high for early stage - try cutting back.

[park_bear]

The idea that prolonged exposure to dopamine replacement drugs leads to dyskinesia is wrong and I have posted on this matter repeatedly. Please pay better attention. This was debunked by the following study: academic.oup.com/brain/arti..., which showed that Parkinson's patients who had never received levodopa were just as prone to dyskinesia as long time levodopa users.

[Bailey_Texas in reply to park_bear]

That myth is slowly being put to rest. Keep posting it

Thanks

[JosieDubbel in reply to park_bear]

For me I donot care when the dyskenesia starts. I think it is worse than the tremor so I try to take as little dopa as possible

[Don_oregon_duck]

Is there any evidence that a PWP with Bradyknesia is a faster decline type of Parkinson's than the other types?

[lempa_nik in reply to Don_oregon_duck]

Don_oregon_duck, By doing a search under "subtypes," you will fetch up extensive posts by Aspergerian on "subgroups and subtypes" of PD. For example, he includes an extensive set of links in this:

healthunlocked.com/parkinso...

The references he supplied will keep you busy for a long time.

In the tiny bit I have read, I have not noticed any subtype grouped according to just Bradykinesia. In following paper, the authors find 4 major subtypes:

" Results:

The analysis revealed four main subgroups: (a) patients with a younger disease onset; (b) a tremor dominant subgroup of patients; (c) a non-tremor dominant subgroup with significant levels of cognitive impairment and mild depression; and (d) a subgroup with rapid disease progression, but no cognitive impairment."

ncbi.nlm.nih.gov/pmc/articl...

You can read up on their group (d) (rapid disease progression) and see if they interest you.