Parkinson's Movement
12,681 members11,272 posts

Psychosis from sinemet?

Anyone relate to this article?

parkinsonsnewstoday.com/201...

30 Replies
oldestnewest

This study muddies the waters by labeling impulse control disorder (ICD*) as psychosis. Psychosis is defined as "an abnormal condition of the mind that involves a loss of contact with reality". ICD is characterized by compulsion, not loss of contact with reality. So the psychosis label is not even true for ICD. Therefore this study should not even have been published with the terminology they have used.

*They also included Dopamine dysregulation syndrome (DDS) which is a form of ICD.

Inappropriate terminology aside , this study examined the correlation between ICD and dyskinesias. It is well-known that dyskinesias are a result of levodopa type medication. However, no examination was made of whether patients were also taking dopamine agonists. Therefore no conclusion can be drawn from the study as to the association between ICD and levodopa medication usage.

Let us take a look at a study that did examine the relationship between medication and ICD, here: Impulse Control Disorders in Parkinson DiseaseA Cross-Sectional Study of 3090 Patients at jamanetwork.com/journals/ja...

“Impulse control disorders were more common in patients treated with a dopamine agonist than in patients not taking a dopamine agonist (17.1% vs 6.9%; odds ratio [OR], 2.72;… Conclusions Dopamine agonist treatment in PD is associated with 2- to 3.5-fold increased odds of having an ICD. This association represents a drug class relationship across ICDs”.

As to the relationship between ICDs and levodopa medication the study finds: “An ICD was present in 17.7% of patients taking both a dopamine agonist and levodopa, 14.0% taking a dopamine agonist without levodopa, and 7.2% taking levodopa without a dopamine agonist. On multivariate analysis, the odds of having an ICD was higher in patients treated with a dopamine agonist than in levodopa-treated patients not taking a dopamine agonist (OR, 2.60; 95% CI, 1.97-3.43; P < .001). The combination of dopamine agonist and levodopa use, compared with dopamine agonist use alone, increased the odds of having an ICD (OR, 1.42…”

7 likes
Reply

Levodopa causes ICD’s on some level in every patient that takes it

Most patients have no idea that they are being impulsive

And WE ALL have DDS as well

It’s how our body reacts to unnatural dopamine

2 likes
Reply

I will take the foregoing carefully done study as well as my own experience over your unsupported claims. It may be true in your experience but that does not make it true for everyone.

6 likes
Reply

Your right

My claims are unsupported

This is just what I believe

Not just from my own personal experience

I’ve been friends with hundreds of pwp and I’ve connected with thousands more over the last 3 years and EVERY one of them showed abnormal impulsive behavior when taking dopaminergic medications

However

Most of them are not impulsive enough to affect their daily lives in any significant way

It’s the unbalance that the medication causes that happens in ANYONE that takes it

If a medication helps with a persons Parkinson’s symptoms than it WILL also cause behavior changes

1 like
Reply

" I’ve connected with thousands more over the last 3 years and EVERY one of them showed abnormal impulsive behavior when taking dopaminergic medications "

Please kindly explain how it is you have connected with these thousands of Parkinson's patients and how you have been able to determine that every one of them has shown abnormal impulsive behavior when taking dopaminergic medications, even though it does not affect their daily lives in any significant way.

3 likes
Reply

Social media

It’s a huge trigger for impulsive behavior

Whenever a pwp would ask if they should start taking medications since they were recently dx’d

That person never logs back in or does so rarely

But pwp on Meds are constantly logging in

That’s just one of many impulsive behaviors I’ve observed

Reply

Which dopamine agonist were u taking Park if you don’t mind me asking?

Reply

So I am supposed to believe you have systematically observed the social media login behavior of thousands of PWP knowing which ones were on medication and which were not. Uh-huh.

2 likes
Reply

There’s nothing “systematic” about my observations

It’s just common sense really

What dopamine agonist are u on if u don’t mind me asking?

Reply

Cumpulsive behavior is just as prevalent as impulsive behavior

Same with obsessive and risk taking behavior

It's all under the dopamine umbrella

As is motor control

If you are having issues with motor control symptoms than ur having issues with behavioral symptoms as well

Dopamine controls all of it all the time

It’s not like sinemet only medicates a pwp’s movement

It medicates behavior as well

The problem is that nothing is wrong with a pwp behavior Aside from depression that is also a symptom of Parkinsons

So sinemet medicates too much in a way

And that causes unbalance in dopamine

Which causes issues with behavior

U don’t have to have extensive medical knowledge to figure this out

It’s just common sense

Reply

I am not taking any dopamine agonist.

It is very interesting your that "observations" turn to be just "common sense". Uh-huh.

3 likes
Reply

Its interesting that your responding immediately instead of tomorrow or the next day

Wouldn’t you say?

That’s just a tad bit on the compulsive side maybe?

Reply

And I don’t base what I believe primarily on observation

At least I hope I don’t

That would leave a huge gap in the self awareness department lol

Reply

compulsive or is it someones job ?

Reply

Park_bear, I agree and support every statement of yours in this thread. Thank you for your reasoned and thoughtful responses.

8 likes
Reply

I've been buying shoes that I mostly don't need and havnt even worn. I've never been a shoe person - never get the jokes about women and shoes - but now have 5 boxes sitting in my bedroom! It's odd as I know I'm acting out of character but don't really care. I don't understand myself really.

Could be worse I suppose!

4 likes
Reply

This is an example of what I’m talking about but most don’t even have behavior changes to this extent

Why even bring it up if it’s not an issue with most pwp?

Because it IS an issue and it hasn’t even been acknowledged by the medical powers that be

It’s a very real and serious issue that will get worse as medications get more potent in the future

Xadago is a medication I started taking 6 months ago and it is helping tremendously but it’s increasing behavior issues just as much

1 like
Reply

My husband was hoping for the sex obsession! But he got shoe boxes in the bedroom!!

8 likes
Reply

Been there done that

He wouldn't like it

Trust me

1 like
Reply

Yes, I do believe I have experienced some mental peccadilloes.

1 like
Reply

goo.gl/images/eT0VUA

goo.gl/images/iT57wC

opposite sides of the spectrum

Reply

Hmm

I don't get it lol

Reply

I have caused some troubles on this site seeking answers. I come by it naturally.

3 likes
Reply

I would say that I have a COMPULSION.

2 likes
Reply

Cumpulsive behavior is just as prevalent as impulsive behavior

Same with obsessive and risk taking behavior

It's all under the dopamine umbrella

As is motor control

If you are having issues with motor control symptoms than ur having issues with behavioral symptoms as well

Dopamine controls all of it all the time

It’s not like sinemet only medicates a pwp’s movement

It medicates behavior as well

The problem is that nothing is wrong with a pwp behavior Aside from depression that is also a symptom of Parkinsons

So sinemet medicates too much in a way

And that causes unbalance in dopamine

Which causes issues with behavior

U don’t have to have extensive medical knowledge to figure this out

It’s just common sense

1 like
Reply

I am still on the same dose of sinemet I started 8 years ago.

4 likes
Reply

Dont try to argue with Serenity, he will always have an answer, and probably one you will not understand, its a brain thing. Happy New Year.

1 like
Reply

What u mean?

Reply

It is my research that the endocannabinoid ( how ever you spell it ) is the neurotransmitter that regulates the other neurotransmitters.

WORKS FOR ME

Reply

WE have so much in common with PTSD patients. Some event or condition threw our brain out of wack.

Reply

You may also like...