Resting tremor: Locus coeruleus in PD : bibliography

Interesting observations in paragraph from first citation.

Neuroanatomical changes in Parkinson's disease in relation to

cognition: An update.


Loss of noradrenergic neuronal and Lewy bodies formation was much

higher in locus coeruleus (LC) than dopaminergic neuronal loss in PD

patients. Resting tremors of PD are due to neuronal loss of LC.[48,49] About 35%

of PD patients were depressed, and loss of noradrenergic pathways

underlies the pathophysiology of depression in PD.[50] The pathological changes in LC of PD

patients are peculiar and can be differentiated from changes that

occur in other neurodegenerative diseases such as schizophrenia.[50] It was reported that simultaneous

lesions of dopaminergic system, and LC causes metabolic dysfunction

in the cerebral cortex and impairs cognitive functions in PD.[51].

See also:

A role for locus coeruleus in Parkinson tremor.

Qualitative and quantitative analysis of locus coeruleus neurons in

Parkinson's disease.

Noradrenergic Modulation of Cognition in Health and Disease.

Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results

in a Correlation of Dopaminergic Neuronal Number to Striatal

Dopamine Concentration.

Biology of Parkinson's disease: pathogenesis and pathophysiology of

a multisystem neurodegenerative disorder.

Noradrenaline and Parkinson's disease.

Differential response of the central noradrenergic nervous system to

the loss of locus coeruleus neurons in Parkinson's disease and

Alzheimer's disease.


2 Replies

Thanks - a lot of links here. Can you summarise this please as I’m not sure what it’s really suggesting?



I'm intrigued by non-motor symptoms in PD, eg, traits linked to the

nucleus basalis and the locus coeruleus. The first study in this thread

credited The first study in this thread's initial post credited the

locus coeruleus in regard to resting tremor. The locus coeruleus is

different from the substantia nigra. Excerpts precede each link.

How is tremor classified? Tremor can be classified into two main categories:

Resting tremor occurs when the muscle is relaxed, such as when the hands

are resting on the lap. With this disorder, a person’s hands, arms, or

legs may shake even when they are at rest. Often, the tremor only

affects the hand or fingers. This type of tremor is often seen in

people with Parkinson’s disease and is called a “pillrolling” tremor

because the circular finger and hand movements resemble rolling of small

objects or pills in the hand.

Action tremor occurs with the voluntary movement of a muscle. Most types

of tremor are considered action tremor. There are several

sub-classifications of action tremor, many of which overlap.

Finally, several SPECT studies have correlated the amount of striatal

dopamine depletion with the severity of individual symptoms. These

studies consistently show that, unlike other Parkinson's disease

symptoms, resting tremor does not correlate with nigrostriatal dopamine

depletion (Benamer et al., 2000, 2003; Pirker, 2003; Isaias et al.,

2007; Spiegel et al., 2007).