Interesting observations in paragraph from first citation.
Neuroanatomical changes in Parkinson's disease in relation to
cognition: An update.
CHANGES IN LOCUS COERULEUS IN PARKINSON'S DISEASE.
Loss of noradrenergic neuronal and Lewy bodies formation was much
higher in locus coeruleus (LC) than dopaminergic neuronal loss in PD
patients. Resting tremors of PD are due to neuronal loss of LC.[48,49] About 35%
of PD patients were depressed, and loss of noradrenergic pathways
underlies the pathophysiology of depression in PD. The pathological changes in LC of PD
patients are peculiar and can be differentiated from changes that
occur in other neurodegenerative diseases such as schizophrenia. It was reported that simultaneous
lesions of dopaminergic system, and LC causes metabolic dysfunction
in the cerebral cortex and impairs cognitive functions in PD..
A role for locus coeruleus in Parkinson tremor.
Qualitative and quantitative analysis of locus coeruleus neurons in
Noradrenergic Modulation of Cognition in Health and Disease.
Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results
in a Correlation of Dopaminergic Neuronal Number to Striatal
Biology of Parkinson's disease: pathogenesis and pathophysiology of
a multisystem neurodegenerative disorder.
Noradrenaline and Parkinson's disease.
Differential response of the central noradrenergic nervous system to
the loss of locus coeruleus neurons in Parkinson's disease and