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Parkinson's Movement
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Alpha GPC?

Hi All, I have been away from my favorite Parkie website since Ron has been dx with Lewy Body Disease, but I have a question and I'm reaching out to you guys, since you Parkies do so much research for yourselves.

Has anyone used or know about Alpha GPC? It's alphaglycerophosphatidylcholine) and is reported to quickly cross the "brain blood barrier" to increase cognitive function.

Thanks for any help you can give me!!!

2 Replies

I have not used it, but according to the book on vitamins, minerals and herbs by Pamela Wartian Smith, MD, Alpha GPC is critical to health, because it makes an important neurotransmitter - acetylcholine which is involved with communication in your brain. Alpha GPC is better absorbed than choline or lecithin, but she doesn't say anything about it crossing BBB.

To treat memory loss she recommends 1,200 mg daily for 1 month and reduce to 600mg daily.

Wish I could help your more, hope someone will be able to provide more information.

There is a website where you can see a few reviews of people who use Alpha GPC:



If he has Dementia with Lewy Bodies then vinpocetine could be of value in terms of preserving cognitive function, and also possibly for sleep disorders. In the early stages of dementia, the main symptoms are caused by deterioration of the brain's own production of acetylcholine. Alpha GPC is the most effective way to raise acetylcholine levels in the brain without major side-effects. Physicians are much more inclined to prescribe acetylcholinesterase inhibitors like donepezil, but these have severe side effects for many patients. Alpha GPC, by contrast, is relative free of side effects for most patients.

To view the literature on Alpha GPC, search for choline alphoscerate. This is the same thing, but the latter term is commonly used in reports on studies.


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