Parkinson's and antioxidants. Interesting article

[parkie13]

sciencedaily.com/releases/2...

[park_bear]

Confirmation that both NAC and Israpadine are beneficial:

"Mitochondrial antioxidants and calcium modulators attenuate the toxic cascade in DJ-1 mutant dopaminergic neurons

We found that long-term treatment with either the mitochondrial-targeted antioxidant mito-TEMPO or NAC blunted the accumulation of oxidized dopamine and improved lysosomal GCase activity and proteolysis (Fig. 3, A to D). Furthermore, because increased Ca2+ entry through Cav1 channels enhances mitochondrial oxidant stress and dopamine synthesis (5, 18), we tested whether Cav1 channel antagonist isradipine (19) or the calcium-dependent serine/threonine phosphatase calcineurin inhibitor FK506 (20) could also regulate dopamine oxidation. Both isradipine and FK506 significantly diminished the accumulation of oxidized dopamine (Fig. 3E), highlighting the importance of Ca2+ in regulating dopamine oxidation in DJ-1 mutant neurons."

This work was done using an animal model.

[Xenos in reply to park_bear]

Phase III with Isradipine is under way (STEADY-PDIII). It ends in November 2018. The dose is 10 mg daily against placebo.

[Jmwg45 in reply to Xenos]

What a shame it's a discontinued drug in the U.K. as of last year or my GP would have prescribed

[aspergerian]

Seems a very important finding1