Parkinson's Movement

Asthma Med Salbutamol Reduces PD risk, Propanolol Increases It

So says a recent study in Science, abstract here: science.sciencemag.org/cont...

"Table 2. Rate ratio for Parkinson’s disease during 2008 to 2014 for salbutamol prescribed during 2004 to 2007 among the entire population of Norway.

DDDs, defined daily doses.

..........................Users 2004–2007........ Cases 2008–2014...... Multivariate-adjusted*

Never user ......................4,201,011 ....................2338 ...................1 (ref)

Low (<60 DDDs) .................152,965....................... 68.................... 0.96 (0.76 to 1.23)

Medium (60 to 180 DDDs).. 72,911........................23 ......................0.60 (0.40 to 0.91)

High (≥180 DDDs)................ 69,511 .......................25...................... 0.45 (0.31 to 0.67)

*Adjusted for age (in 5-year periods), sex, and level of education ...

Evaluation in additional populations and in clinical trials will be required to determine whether the insights gained in this work can be translated to patients with PD. "

The PD risk for propanolol users was about double vs. the general population.

There have been some studies of salbutamol in PD showing its use did result in modest improvement: scienceofparkinsons.com/201... (H/T parkie13)

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