I have come to the conclusion that you will not be able to use symptoms to category Parkinson.s. The next step would be to categorize medications and are they helping your symptoms. You should be diagnosed for at least 3-4 years and there should also be the question are you happy with the results.
So for me the questions would be , ( Do you take Dopamine to help with physical movement? ) ( How much do you take?) ( Are your symptoms better or worse if you take extra?) ( Does any other medication help you with movement and if so what. )
This would be for the physical state.
my bio would be :
Dopamine: used for movement- to much leads to rhythmic and painful muscle contractions
Amantadine: used for muscle relaxation
Pramopaxil: used in conjunction with dopamine- to much makes me myopic and ultra focused.
Sertraline: used to treat anxiety and anxiety related movement- at maximum dose.
CBD/ THC therapy: loosens muscles, relives tension, relives anxiety, makes me more coherent.
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Serenity_finaly-1
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What about the argument, which I believe has some merit, that PwPs should be divided into various subgroups which is based around the concept that Parkinsons is not a single disease but is better described as a syndrome - it derives from a number of sources, and that one of the reasons that we're not seeing more definitive results out of clinical trials is that participants really represent a mixed bag of subtypes of Parkinsons. Participant selection seems primarily concerned with other medical conditions of health or simply the stage of the disease.
Another reason is that very different basic subgroups like Early Onset, late Onset have dramatically different longevity prospects or other basic differences such as prevalence of dementia. It's quite small for those that fall in the group Tremor at Rest but upwards of 70% for those who are Posture Instability Gait Disordered.
And that my dear Sir is the problem. I am becoming more clear that you can not go by symptoms but what is done to relive those symptoms. By addressing the chemical imbalance in the brain we could find what part of the brain is affected. It would stand to reason that to if protein clumps are interfering with dopamine production that it would interfere with the production of other neurotransmitters, maybe even caused by the lack of dopamine.
I agree with you in that PD should be catagorized as a syndrome. I was diagnosed in 11/16 at age 71, after years of accumulated symptoms. Everyone I've met with PD has such a wide array of symptoms . They don't have my symptoms and I don't have theirs. I've raised a child with autism and in my opinion PD is just like being on the Autism Spectrum.
We are a complex system, to only consider dopamine supplementation as treatment for PD (and other neuropathies) is a disservice to the patient. It does no harm to use complimentary therapy, but get support from an alternative medicine practitioner.
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