New Clinical Study regarding Mucuna Pruriens

[karolmilk]

New clinical study, 7-5-2017, with favorable results:

neurology.org/content/early....

file:///home/chronos/u-8b40ef9cb254ff0ea96c75f9b97bc580835e5dc1/Downloads/Cilia%20R.%20Mucuna%20in%20PD.%20Neurology%202017,%20432-438.pdf.

Mucuna pruriens in Parkinson disease. A double-blind, randomized, controlled, crossover study

ABSTRACT

Objective: To investigate whether Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in all tropical areas worldwide, may be used as alternative source of levodopa for indigent individuals with Parkinson disease (PD) who cannot afford long-term therapy with marketed levodopa preparations.

Methods: We investigated efficacy and safety of single-dose intake of MP powder from roasted seeds obtained without any pharmacologic processing. Eighteen patients with advanced PD received the following treatments, whose sequence was randomized: (1) dispersible levodopa at 3.5 mg/kg combined with the dopa-decarboxylase inhibitor benserazide (LD1DDCI; the reference treatment); (2) high-dose MP (MP-Hd; 17.5 mg/kg); (3) low-dose MP (MP-Ld; 12.5 mg/kg); (4) pharmaceutical preparation of LD without DDCI (LD2DDCI; 17.5 mg/kg); (5) MP plus benserazide (MP1DDCI; 3.5 mg/kg); (6) placebo. Efficacy outcomes were the change in motor response at 90 and 180 minutes and the duration of on state. Safety measures included any adverse event (AE), changes in blood pressure and heart rate, and the severity of dyskinesias.

Results: When compared to LD1DDCI, MP-Ld showed similar motor response with fewer dyskinesias and AEs, while MP-Hd induced greater motor improvement at 90 and 180 minutes, longer ON duration, and fewer dyskinesias. MP-Hd induced less AEs than LD1DDCI and LD2DDCI. No differences in cardiovascular response were recorded.

Conclusion: Single-dose MP intake met all noninferiority efficacy and safety outcome measures in comparison to dispersible levodopa/benserazide. Clinical effects of high-dose MP were similar to levodopa alone at the same dose, with a more favorable tolerability profile.

ClinicalTrials.gov identifier: NCT02680977. Neurology® 2017;89:432–438

[PDConscience]

If this study looks oddly familiar, a summary and link to the same study was posted 3-4 weeks ago in response to the Mucuna Prurians question/post by 'Lynnie1':

healthunlocked.com/parkinso...

[y8bam2]

Our neurologist stopped pushing sinemet and started encouraging me to continue with my mucuna after he read that study( I have been using mucuna for 2 years with good results-better since I mix pills with powdered organic form-contains some serotonin as well)

[moparkie715 in reply to y8bam2]

hi Y8bam2,

I was wondering what symptoms you have that mucuna has helped you with?

[y8bam2 in reply to moparkie715]

It's the same form of dopa as the one in sinemet-but minus the carbidopa-AND in the powder form is a complete food-a bean- that contains serotonin and other good stuff. unlike the MP extracts. It's been tested by the experience of 4000 years to present in India and elsewhere of being used for animal fodder and by humans.I seem to be able to just take as much as I need(-when the drooling panic .and"out") and I'll come back "in",etc.) .I"ve had PD for 12 years and came off sinemet to avoid the discinesia (sp.) and other side effects it causes -and don't have them.I rotate among MP tablets, capsules and the powder -( recommended to avoid developing a resistance to one form ). AM more careful with dosage amounts with forms with more dopa per serving and therefore less of the other parts of the mucuna ..But as important as the dopa is the movement I need to do and hate doing.... .

[moparkie715 in reply to y8bam2]

do you know if C/L does nothing positive for me, will the MP work?

[y8bam2 in reply to moparkie715]

everyone's PD is so different and there no scientifically proven reason for it just being the substania negrans failure as the cause. However,MP bean is a food.. So it does contain not only the dopa w/o harmful carbidopa and its sideffects but many other substances (-none proven harmful yet.) It also functions for a longer period than C/L. Google "studies about MP contents " etc, They've found substances that help Diabetics, and some researchers think that there must be some factors other than the dopa in the MP bean that help PD folks. EG. When I take the powder my Psoiasis improves some. When I take the more potent extract MP forms( like NOW or Source Naturals) this isn't true. The higher the supplement's potency the less of the other beneficial factors are available (4%6% dopa is in the MP bean naturally-Now is 15%,etc. )

[BUZZ1397 in reply to y8bam2]

I've been thinking about what you just wrote about the powdered MP. I hope that it is truly of greater benefit to take the natural not concentrated bean. That would certainly make treatment simpler no inhibitor required.

[y8bam2 in reply to BUZZ1397]

Yes. I use different powders and have found with all of them fine Have also learned .that they need refrigeration to keep dopa potency. Normally MP is combination of tan and black beans. Different powders may vary a little in color because of this. But that's separate from what happens when there's a thin black sediment in the glass awhile after you finish the drink. or sometimes there's a ring of black on the counter .- I'm not certain but I think its dopa in the powder. that got processed too soon because the powder was too warm at room temp

Because .when I started refrigerating the powder this stopped.

[JANVAN in reply to y8bam2]

Very interesting >>>> where in generally do you order your MP-Powder ??

[JANVAN in reply to y8bam2]

Where is your neurologist living and address (name isn't necessary)-----