Does CQ10 and Vitamin E help with early stages of PD?

[Sudhap]

Hello

I have early stages of PD , does anyone know whether CQ10 and vitamin e are beneficial ?

Thanks

[aspergerian]

Ubiquinol is said to be more effective. A new study found the combination of amega-3 and vitamin E to help in pwp.

[Bitsy]

q10qh.com/ubiquinone-or-ubi...

[aspergerian in reply to Bitsy]

Bitsy, That link seems important. Thank you.

[aspergerian]

Here are several cites (from among many) about PD ans CoQ10.

Randomized,

double-blind, placebo-controlled pilot trial of reduced coenzyme

Q10 for Parkinson's disease.

Parkinsonism

Relat Disord 2015 Aug;21(8):911-6.

ncbi.nlm.nih.gov/pubmed/260...

[In the abstract, methods and results merit attention.]

Does

high-dose coenzyme Q10 improve oxidative damage and clinical

outcomes in Parkinson's disease?

Antioxid

Redox Signal 2014 Jul 10;21(2):211-7.

ncbi.nlm.nih.gov/pubmed/244...

"Subjects with symptomatic benefits from CoQ10 (decrease in total

UPDRS >10 points) had lower baseline plasma ubiquinol (p=0.07,

Mann-Whitney U test) and decreased F2-isoprostanes per unit

arachidonate (p=0.04, Wilcoxon Signed-Ranks test). These results

lead to the hypothesis that the therapeutic response to CoQ10

depends on baseline levels of ubiquinol and whether the dosage of

CoQ10 used can ameliorate the burden of oxidative damage."

Coenzyme Q10

deficiency in patients with Parkinson's disease.

J

Neurol Sci 2012 Jul 15;318(1-2):72-5.

ncbi.nlm.nih.gov/pubmed/225...

"Compared to cases, PD patients had a significantly greater odds of

deficiency in coenzyme Q10 status (OR: 4.7-5.4; 95% CI: 1.5-17.7;

P=0.003-0.009) based on FIA results, but not of vitamin E, selenium,

lipoic acid, or glutathione (all P>0.05). The proportion of cases

with coenzyme Q10 deficiency was also significantly greater in cases

than in controls (32-36% vs. 8-9%; P=0.0012-0.006)."