PD subgroups and subtypes - excellent rhe... - Cure Parkinson's

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PD subgroups and subtypes - excellent rhetoric

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First paragraph in Shoji et al 2014 presents distinctions among PD's

major subtypes and and subtypes within the major groupings. The

study's first paragraph is here presented by separating some of the

sentences

Neural substrates of cognitive subtypes in Parkinson's disease: a

3-year longitudinal study.

Shoji Y, Nishio Y, et al; PLoS

One 2014 Oct 20;9(10):e110547.

ncbi.nlm.nih.gov/pmc/articl...

The cognitive features of Parkinson's disease (PD) are heterogeneous

and can be categorized into several major subtypes.... However, the

neural substrates underlying the cognitive subtypes remain to be

elucidated. Recent studies have demonstrated that there are

correlations between cognitive impairment and non-cognitive features

in PD: patients who develop dementia have a higher age of onset,

rapid symptomatic progression, anosmia and a non-tremor-dominant

motor subtype....

Consistent with these observations, neuropathological studies have

suggested that the anatomical distribution of Lewy-related pathology

differs depending on the clinical subtypes. The pathology rapidly

evolves from the brainstem into the cerebral cortex in patients with

the non-tremor-dominant motor subtype and/or dementia, whereas it is

relatively confined to the brainstem for a longer period of time in

patients with a tremor-dominant motor subtype and no cognitive

impairment....

If such provisional clinico-pathological relationships are genuine

and if specific subtypes of cognitive impairment are associated with

the future development of dementia, these cognitive subtypes may be

associated with specific clinico-pathological subtypes.

.

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