Documentary Completion

Can't wait to listen to it Mary

Excellent work, Rich.

The studies saying that levodopa intolerance is caused by levodopa-induced DNA methylation seem to be in conflict with academic.oup.com/brain/arti... which concludes: " We conclude that motor fluctuations and dyskinesias are not associated with the duration of levodopa therapy, but rather with longer disease duration and higher levodopa daily dose. Hence, the practice to withhold levodopa therapy with the objective of delaying the occurrence of motor complications is not justified."

Your comments?

The following article says it all:

"Chronic treatment with levodopa (LD) in Parkinson's disease (PD) can cause drug induced dyskinesias. Mucuna pruriens endocarp powder (MPEP) contains several compounds including natural LD and has been reported to not cause drug-induced dyskinesias. We evaluated the effects of Mucuna pruriens to determine if its underlying mechanistic actions are exclusively due to LD. We first compared MPEP with and without carbidopa (CD), and LD+CD in hemiparkinsonian (HP) monkeys. Each treatment ameliorated parkinsonism. We then compared the neuronal firing properties of the substantia nigra reticulata (SNR) and subthalamic nucleus (STN) in HP monkeys with MPEP + CD and LD + CD to evaluate basal ganglia circuitry alterations. Both treatments decreased SNR firing rate compared to HP state. However, LD+CD treatments significantly increased SNR bursting firing patterns that were not seen with MPEP+CD treatments. No significant changes were seen in STN firing properties. We then evaluated the effects of a water extract of MPEP. Oral MPWE ameliorated parkinsonism without causing drug-induced dyskinesias. The distinctive neurophysiological findings in the basal ganglia and the ability to ameliorate parkinsonism without causing dyskinesias strongly suggest that Mucuna pruriens acts through a novel mechanism that is different from that of LD."

hindawi.com/journals/ecam/2...

I believe this article is included in the second chapter about the Hinz protocol (Amino Acid Management of Parkinson's Disease).

I have been taking 800 mg - 1,000 mg/per day of 100% pure levodopa from MP for about 4 years (with other components) and have 0 side effects. Part of the problem with any form of levodopa (synthetic or natural) is they can cause niacin deficiency. Carbidopa/benserazide cause pyridoxine deficiency. These facts were known in the 1970's and both of these deficiencies are also part of the problem.

GPR109a (the iodine chapter):

Low-dose niacin supplementation modulates GPR109A, niacin index and ameliorates Parkinson's disease symptoms without side effects

onlinelibrary.wiley.com/doi...

PS. I designed this documentary like a combination of an onion and a puzzle. There is different and additional information about the same subject as it progresses.

Firstly R congratulations on your dedication and work in completing this project. I look forward to watching, i am imagining It will take a while and the effect on my brain may mean i am excused from suduko for the duration. Nice to see you around again.

Subject change:

Im not convinced that the reference above answers park bears query.

The Brain Article (July 2014) is a large human study.

"In this 4-year multicentre study, we investigated a large cohort of patients with Parkinson’s disease in a sub-Saharan African country (Ghana), where access to medication is limited and the initiation of levodopa therapy often occurs many years after onset. The primary objective was to investigate whether the occurrence of motor complications is primarily related to the duration of levodopa therapy or to disease-related factors. "

Your article (2012) is about 16 moneys treated with Mucuna.

I previously read the article quoted by PB. My issue is synthetic levodopa treatment causes dyskinesia, either now or later, and natural levodopa does not. One thing to consider is from the article I quoted the researchers used 'endocarp powder', which contains only 5.5% levodopa. Zandopa, HP-200, contains only 3.3 percent levodopa and yet both of these supplements have been shown to relieve PD symptoms in patients who previously used synthetic levodopa. Additionally, a small, random, double blind cross over trial of 8 patients and the results showed the 8 PWP had a better response while taking 40% levodopa/MP than an equivalent amount of synthetic levodopa. It is my opinion Sinemet is not a good drug and hence all the new alternative forms being made available. If Sinemet worked effectively Rytary, inhaled, melevodopa (the methyl ester of L-dopa), subcutaneous L-dopa......would not be needed. It is the elephant in the room for PD therapeutics. Additionally, those of you who use Sinemet if you can get your hands on Madopar - levodopa/benserazide, you should do so because Madopar is a better drug than Sinemet. Lower doses of Madopar are required to produce an equal amount of dopamine with a larger dose of Sinemet. My father used 25/250 Sinemet 4 times a day and it did not go well.

Congratulations and many thanks, Rich! We are so lucky to have you in our HU group! I can tell from watching the segment on drinking coffee and smoking that I definitely need a fresh brain for all this info, so will watch bit by bit and I look forward to all the informed comments and questions that will surely arise in our forum here.

Can't wait to see this RIch. Congrats! Deb

Well, I did watch it and I for one am glad that you still have to pay the bills. It is complex but simple. I thought it was a little slow but soon came to find that the length of the presentation, which is extremely comprehensive, was just right for the length.

I narrated almost everything considering that some people may not have proper eye sight. Yes it is long but focussed on it's content. There were multiple times I was in a state of disbelief over some of the information I uncovered. My favorite quote was from 1902 in regards to the 'uric acid diathesis'. I almost fell out of my chair when I first read the quotation.

As for paying the bills, I did so but with no financing I had to gut it out and finish the job. I thought about using kickstarter but they stated that 'no dietary supplements' could be included....that was a killer for me.

I have found my time on this site a little confusing, kind of a fish out of water sort of thing. I don't know if I am slow or just naive. I understand that I have a difficult time explaining things clearly now but I will use the best clips of movies to get my point across.

I'm dyin 🤣🤣🤣🤣

Serenity_finaly-1

Hilarious yet soo true !!

I am traveling at the moment and only have access from my phone. Watching on my tablet will be a top priority once I am home.

I watched three parts of your videos.....very interesting. have to think more about it, but I can feel it brewing already.

the bird's eye view tells me, that gov't types would have an interest in deciphering dopamine, and not for the common good only. obviously I don't trust this acadamia.

long narrative, but if you consider orwell's book, and note hitler's hand tremors;(they were eating amphetamines like manna from heaven....) apparently, kennedy was prescribed something similar for his back by a german doctor; who had a hole cluch of them hooked on this, marylin included, throw into that (I don't know if it was shopped but) I think I spyed with my little eye tat putin betrayed a weakness of one of his arms, and you might have a chemical warfare of a kind that lets you targrt individuals and not armies.

for another, it's become imperative or been made imperitive that movement disorders be understood because of the cost of medicare or Obamacare.

all for now. good work, going a ways to understand the environment's contribution to this scourge.

a drooling zombie kim what ever is not so scary, eh?

I read some where that Putin's arm does not swing because he has trained it not to. KGB training.

I think we read the same item.

Hi Rich,

Congratulations are in order. Very enjoyable to sit and listen to your presentation, a plethora of ideas.

I will be reinstituting some of the suggestions. What you have given to all is a porthole that we can revisit again and take what we feel is beneficial to us.

You sounded relieved that it was done however next step would be writing a book and expending all the ideas. I have not seen anything out there that came even close to your format

Thank you Mary

Thanks Mary,

The credits are not finished and only 5 of the 16 sections are complete so I still have a lot of work to go.

I made the doc as a resource to be revisited hence the information overload. As for a book?? I need some R & R (some fun too) because lacking any financial backing I had to make the minimal amount of money to pay the bills to maximize the amount of time I had to work on it. Consequently it drained my finances. To add insult to injury, kickstarter said 'no dietary supplements' in a project so I lost this possible source of income.

All in all it was a great experience and I learned so much working on the doc.

Back at it here...

Rich

Rich, what is the kickstarter?

Here is the Wikipedia patron Kickstarter:

"Kickstarter is an American public-benefit corporation[2] based in Brooklyn, New York, that maintains a global crowdfunding platform focused on creativity.[3] The company's stated mission is to "help bring creative projects to life".[4] Kickstarter has reportedly received more than $1.9 billion in pledges from 9.4 million backers to fund 257,000 creative projects, such as films, music, stage shows, comics, journalism, video games, technology and food-related projects.[5]"

en.m.wikipedia.org/wiki/Kic...

Thank you I had no idea Mary

I added my name to the link to the documentary so the old link will not work. Here is the new address:

vimeopro.com/user60766261/r...

Excellent.

Thanks for being so good at putting together a respectable presentation. Always kind and helpful.

Hey my friend. The cardiologist that is mentioned within the segment about COQ-10 is my cardiologist, Peter Langstroen of Ty;er Texas. What a coincidence.