I recently came across an article produced by the Cleveland Clinic which was an eye-opener. It said "While Sinemet is the most effective medicine and has the least short-term side effects, it is associated with high risks of long-term side effects, such as involuntary movements (dyskinesia). Used on a long-term basis, levodopa might also cause restlessness, confusion or abnormal movements. Changes in the amount or timing of the dose will prevent these side effects but most experts now recommend alternatives to Sinemet, such as the dopamine agonists, and use Sinemet only when the alternative fails to provide sufficient relief.
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