Ramón Cacabelos, a world known expert for neurodegenerative disorders and genomic medicine, and his team have completed preclinical and clinical studies with a nutraceutical called AtreMorine. The exceptional results shows that AtreMorine protects selectively dopaminergic neurons and significantly increases naturally the dopamine level in the organism and without any reverse effects.
Dr. Ramón Cacabelos is Professor of Genomic Medicine at Camilo José Cela University, Madrid, and President of the EuroEspes Biomedical Research Center, Corunna, Spain. He received his M.D. from Oviedo University, Ph.D. from Santiago University, and D.M.Sci. (Psychiatry) from Osaka University Medical School, Japan. After a decade at the Department of Psychiatry in Osaka, he returned to Spain and focused his research activity on the genomics and pharmacogenomics of neurodegenerative disorders. He has published over 600 papers and 24 books, and is Editor-in-Chief of the first World Guide for Drug Use and Pharmacogenomics and President of the World Association of Genomic Medicine.
This study was recently published in the “Journal of Genomic Medicine and Pharmacogenomics Scitcentral” with all references to the pre-clinical and clinical results of this nutraceutical whose scientific name is E-PodoFavalin-15999, distributed under the name AtreMorine.
Whilst this looks too good to be true this Dr is bona fide and an eminent specialist in Spain so maybe we should watch this space. You can read the research here
You have to take 5g 2-4 times a day and there's 79 g in a pot. It costs between 62 E and 92E depending on how much you buy so you could be looking at 250E + a month. So I think I'll be taking a raincheck on this one and carry on eating broad beans every day!
I had it just the once. It is horrible to take and did not do anything to my tremors. They say Big Pharma is a rip off but supplements are not far behind though Mucuna by Zandu is fairly reasonable. I will stick with mucuna for the moment.
I use Zandu Zandopa from India Take one spoon supplied. Think it is 7.5g. Not sure if it works to be honest but have been stable for 2 years. Only fair to say I also take £250 worth of supplements a month as recommended by a Parkinson nutritionist.
I was thinking of getting one bottle, and if it worked as the feedback indicates, taking it for (a day or two before) social events out. Looks like if you buy 4 bottles, it's $62 per, plus I think there is a 20% discount for 1st time purchase which would cover shipping. If we could find two others to go in on a 4 bottle purchase, would you be interested? 1) why isn't this being shouted from the roof tops, i.e., it's unheard of on the PD forums I've checked - except you raised it on this forum 4 mos ago. I can only find user feedback on AtreMorine's link to their Facebook site -- which they control. 2) Since excess L-Dopa/dopamine causes dyskinesia, might this stuff cause severe dyskinesia? I'm furiously doing research, am highly suspicious, but willing to try 1 bottle.
Yes he's right it is a supplement and he's quite right it can't cure ,slow down ,halt or reverse PD but then neither can any of the Pharmas we are prescribed!
This stuff looks like a scam. There is no way it is better than sinemet as they both have the same active ingredient (L-Dopa) and this stuff would be harder to titrate the right dosage.
If you read the research it doesn't say it's ibetter than Sinemet ,it works longer up to 12 hours without the side effects,,and if used in conjunction with Sinemet the Sinemet dose can be significantly reduced.
The study reveals precisely that co-administration of nutraceutical AtreMorine with antiparkinsonian drugs, allows a reduction of the conventional medicine dose between 25 to 50%, with clinical benefits and significant reduction of short and long term adverse of these drugs. Consequently, patients could use antiparkinsonian drugs over a much longer period.
Actually , another independent study says that Atremorine provides no clinical benefit over sinemet. In fact the study said that sinemet is actually better as the dosage is more precise. Why would anyone need to take the product with sinemet? Why not just take another capsule of the sinemet? Basically this guy selling it should be ashamed of himself. He is just a scammer trying to rip off PD sufferers with a product that provides absolutely no benefit over what everyone is already taking. It would be like me selling Macuna Pruriens and stating that it is a magical cure for PD because it has naturally occurring L-Dopa in it. Total scam.
One last thing, the "study" you mention was performed by the same people selling it. Talk about a conflict of interest. This type of thing shows even more that it is scam.
I found by mixing 1/3 Atremorine powder with banyan mucuna powder and taking one TS of the mixture with water after taking my sinemet 100/25 gives me a good result and long effect , I think Atremorine needs carbidopa to work .
A friend and I asked a professor of Neurology and his Research Fellow at Bristol University (UK) to check this out for us. This is his reply.
We were disappointed at the time, but with hindsight, better to be safe than sorry.
We are now taking Mucuna Pruriens - and both doing very well on it, in spite of the warnings about the unreliability of "natural substances"
We both had unpleasant side effects after taking SInemet ( in my case) and Madopar ( in hers) so wanted to try a more natural substance.
Anyway, here are their comments ...
"As promised K........ and I have been doing some research around Atremorine and Ramon Cacabelos.
In short, we are not convinced by either of them!
Beans and in particular Vicia faba (Broad beans) do contain dopamine precursors (like levodopa). However the precise amount of levodopa in each bean/plant is hard to control and therefore this type of natural supplements can be unreliable.
There is an official response from Parkinson's UK about AtreMorine. Kirsty and I are in complete agreement with it. Please see below:
“AtreMorine is a supplement made from broad beans (Vicia faba). Broad beans can provide a natural source of levodopa, the chemical building-block that your body converts into dopamine and the 'active ingredient' found in some conventional Parkinson's medications. Natural sources of levodopa, such as AtreMorine work in the same way as Parkinson’s medications, which work to replace dopamine and help ease symptoms. However unlike with Parkinson’s medications which are of known doses, it’s hard to control the amount of levodopa you receive with natural sources.
We would encourage anyone with Parkinson’s who is thinking about trying supplements to speak to their specialist or Parkinson’s nurse. We also urge people to be cautious when buying supplements over the internet and be aware that they are not subjected to the same careful safety testing and monitoring as approved medical treatments”
We also did our own digging. What we found made us question both Atremorine and Ramon Cacabelos' "science". This is what we found (don't worry, we won't be offended if you do not read it all )
Ramon Cacabelos
He did study Medicine in the University of Oviedo (Spain) and did his PhD in the University of Osaka (Japan). He has had several academic positions in the past but all quite short. At the moment he is not working in any University (so not really a professor). You can have a look at his professional profile here es.linkedin.com/in/ramón-ca...
He has been president of EuroEspes, a private research centre, for more than 10 years. What research outputs or what the centre does are not clear. Which scientists or doctors work on that centre is not clear either... euroespes.com/en/gallery/
Cacabelos was in the Spanish news about a possible cure for Alzheimer’s in 2012. But this has not progressed any further (I have some links in Spanish if you want to read?)
Buying Atremorine
K....... and I are not convinced by the reviews on the Atremorine website
There is only 5 reviews and two seem to have been written by the same person (use very similar language).
From a scientific point of view, Cacabellos claims about Atremorine come from two publications:
1. Journal of Genomic Medicine and Pharmacogenomics (2016). This publication is about a trial in people with parkinsons. It is not a good study and the results are not convincing. All they did was give 5 grams of Atremorine and then look at the effect in dopamine level after one hour! No long term follow up, no other physical or cognitive tests...
A bigger problem is that Cacabellos himself is the editor in chief of this journal. Which means that he could have published this without going through appropriate scientific tests and peer-review.
2. Current Pharmacology Design in 2017. This publication covers the preclinical tests for Atremorine in mice (odd that preclinical tests get published after the clinical trials in people!). The journal is obscure and nor the University of Oxford or the University of Bristol subscribe to it (which is not a good sign as we do subscribe to most respected / accepted journals). Not convinced by it.
So there you go! I hope this helps you make up your mind. But again, if you do decide to try AtreMorine, please discuss this with your specialist.
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