Zonisamide...new drug for Parkinson's? - Cure Parkinson's

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Zonisamide...new drug for Parkinson's?

Blackfeather profile image
6 Replies

ncbi.nlm.nih.gov/pubmed/205...

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Blackfeather
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park_bear profile image
park_bear

I did use Zonisamide for a while early on and it did seem to help with tremors. I didn't realize it did all these good things:

"effects on Parkinson's disease include activation of dopamine synthesis, inhibition of monoamine oxidase,... and markedly increases glutathione S-transferase levels in the striatum by enhancing the astroglial cysteine transport system "

Glutathione is what we are trying to enhance by taking NAC.

Joanne_Joyce profile image
Joanne_Joyce

Ann Neurol. 2010 Feb;67(2):239-49. doi: 10.1002/ana.21885.

Neuroprotective effects of zonisamide target astrocyte.

These results provide new pharmacological evidence for the effects of ZNS. ZNS markedly increased GSH levels by enhancing the astroglial cystine transport system and/or astroglial proliferation via S100beta production or secretion. ZNS acts as a neuroprotectant against oxidative stress and progressive dopaminergic neurodegeneration.

Blackfeather profile image
Blackfeather

My doctor prescribed zonisamide for me, so we will see. I will let everyone here know my results. I'm excited about this drugs potential benefits.

Carolinagirl123 profile image
Carolinagirl123 in reply to Blackfeather

hey, let me know how it goes!

jaberalhddad profile image
jaberalhddad

Any updates from the users of zonisamide ?

onlinelibrary.wiley.com/doi...

Blackfeather profile image
Blackfeather in reply to jaberalhddad

I've had to hold off on taking zonisamide because I am trying to taper off of fentanyl pain patch, which will probably take about a month. Just didn't want to have to much to deal with at one time.

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