Parkinson's Movement

Parkinson’s Disease Psychosis, particularly hallucinations

Most symptoms appear to be due to disease pathology with exacerbation caused by dopaminergic treatment. More than 50% of patients with PD develop psychosis at some point throughout their disease course. Clinicians need to routinely assess patients with PD for psychotic symptoms, particularly hallucinations. Treatment of psychotic symptoms in PD is an unmet need as there are currently no US Food and Drug Administration (FDA) approved medications specifically for PD psychosis (PDP).

Current treatments for PDP have been adapted from dopamine antagonists used to treat psychosis in other conditions, such as schizophrenia. Typical antipsychotics, as well as some atypical antipsychotics, worsen PD motor symptoms due to blockade of dopamine D2 receptors. Quetiapine and clozapine have been studied in PDP and are the most commonly used treatments for PDP.

Clozapine has been shown to be effective; however, regular bloodwork is required, while data for quetiapine are inconsistent. Pimavanserin, a highly selective serotonin (5HT2A subtype) receptor inverse agonist, is not associated with motor worsening in PDP patients due to the absence of dopamine blockade. In a double-blind, placebo-controlled study, pimavanserin showed significant improvement in moderate to severe psychosis compared to placebo, with good tolerability and without worsening of PD motor symptoms. These data suggest that pimavanserin is a safe and efficacious treatment for PDP psychosis and could be a potential new treatment option for PDP.

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Apropos of your post:


May be helpful in treating schizophrenia and many more of psychological disorders because it has been shown to restore glutathione levels in the brain.

It is a serotonin modulator and is a quote safe and useful on quote formula for treating Behavioral and psychological symptoms of dementia and borderline personality disorder. That study also shows a statistically significant Improvement intarditive dyskinesia, psychosis, schizophrenia.

It is used for Disturbed dreams, insomnia, spasms also it has neuroprotective

In Chinese medicine it is used for Parkinsons with good results.


Yes, Pimavanserin was recently approved specifically for PD psychosis. In company sponsored trials it performed as you have stated. Hopefully it will live up to its promise. If anyone, patient or caregiver, has, or gets, experience with this please post!


A new review:

Management of Psychosis in Parkinson's Disease: Emphasizing Clinical

Subtypes and Pathophysiological Mechanisms of the Condition.

Parkinsons Dis 2017;2017:3256542 Epub 2017 Sep 12.


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