Recently I found that I needed more and more Sinemet and still could not effectively manage tremor. After noting anything and everything that had occurred or I had changed about my routine that may have caused the exacerbation, I started reversing course. Finally discovered it was a B vitamin complex that I started taking. I am back to "normal" doses of Sinemet after one day not taking that B-complex product. The B-complex product that caused the trouble is FINEST brand, quick dissolve SUPER B-COMPLEX wild berry flavor (artificial flavor) distributed by Walgreens. Don't know what is in it that led to the problem but it is inadvisable to take it, in my opinion.