A couple of days ago someone on this site asked me what the difference was between these two after I had posted that Sinemet made me confused whereas Madopar was almost miraculous in its effect.
I'm afraid I can't find the original question but the difference is that Sinemet is ldopa combined with carbidopa whereas Madopar (also known as Co-beneldopa)is combined with benserazide. Both carbidopa and benserazide help the ldopa cross the blood-brain barrier. Some people tolerate either of these equally well; others are less able to tolerate one or the other - for some reason carbidopa was not compatible with my brain! I also take a COMT inhibitor (Entacapone) and an MAO(BAz)Inhibitor (Azilect) which slows down the enzyme which breaks down ldopa. I also take Amantadine which minimises dyskenesias although these are beginning to become more noticeable. I take 100mg madopar and 200mg entacapone every 3 hours,
i find increasingly that it's pretty disastrous to eat protein at anytime as the ldopa stops working and my body stops functioning and feel really terrible. (no idea why that went italic but worried if I try to changeit I will lose the whole post)