Have been on25/100 sinimet 3 x a day and have done fine. Have been under a lot of stress and poor diet because of caring for my husband. I have recently started to have sore knees and a tired feeling in legs. Could this be the pd advancing. I have not slept due to my sick husband.Wondering if I should up the dose a bit or is it something else. I am on my feet from daylight to dusk and know longer have time for the gym.