Important Drug Approval for Parkinson Patients

Nuplazid, which the FDA designated as a breakthrough therapy and granted priority review, could help approximately 50% of Parkinson patients.

Parkinson disease patients with associated psychosis now have a better option to treat hallucinations or delusions, which occur in approximately 50% of patients over the course of their disease. That’s because in April the U.S. Food and Drug Administration (FDA) approved Nuplazid (pimavanserin), a first-of-its-kind drug designed to treat psychosis due to Parkinson disease. - See more at:

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  • That "approximately 50%" more like 40%, but more importantly PD sufferers typically only develop psychosis late in the course of the disease. So it's more like 40% will /eventually/ be candidates for this drug. Also, for those who have hallucinations but retain insight, caregivers will not be pressing patients to take this.

    That said, it seems this drug is a big improvement over what is out there for patients who require this kind of medication.

  • I watched on you tube LDN DROGS IN LOW DOSE can reverse PD

    any one used this drug?

  • Low Dose Naltrexone (LDN) has been tested with Parkinson's patients and does decrease fatigue. LDN is taken at bedtime starting at 1 mg and eventually raised to 4.5 mg - over several months in a step wise progression: 1 mg - 1 month, 3 mg 2nd month, 4.5 mg third month. It is an opoid antagonist which, at full dose, 50 mg, is used for opoid dependence.

    At the lower dose it has been tested against diseases like Crohn's, fibromyalgia, MS....and Parkinson's.

    Here are several articles about LDN/Chronic Fatigue & fibromyalgia:


    LDN has to be produced through a compounding pharmacy and it costs about 20-50 dollars a month. My father tried LDN and it worked fine and he showed improvement. LDN can be purchased without a doctors prescription through the following website:

    While on LDN you cannot be on opoid pain killers because LDN is an opoid antagonist. You can buy it through the above link(without a doctor's prescription).

    Here is more info about LDN and Parkinson's:


    Naltrexone hydrochloride is contraindicated in:

    1. Patients receiving opioid analgesics.


    Patients currently dependent on opioids, including those currently maintained on opiate agonists (e.g., methadone) or partial agonists (e.g., buprenorphine).


    Patients in acute opioid withdrawal (see WARNINGS).


    Any individual who has failed the naloxone challenge test or who has a positive urine screen for opioids.


    Any individual with a history of sensitivity to Naltrexone hydrochloride or any other components of this product. It is not known if there is any cross-sensitivity with naloxone or the phenanthrene containing opioids.


    PS. Naloxone is used for drug OD whilst naltrexone is used for dependence - they have common chemical properties, and naloxone has been shown to be a possible therapy for PD:

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  • Use ldn now for a year with no effect

  • Physc prescribed Nuplzid for my spouse. Will try to let every one know what happens and if it works. Been 3 weeks waiting on the 6 week mark, I hope it works. It is not cheap but their is an assist fund available.

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