I'm going to order the following plant extracts in bulk from China as powders and mix them for storage and later mixing in drinks.
I'll dump the powders in a 5 gallon bucket, shake, bottle, and label according to FDA. I'm already taking about 2/3 of them. Let me know if I'm missing anything. I take 1 tablespoon of the powder twice a day mixed in a juice/wine.
The dose simulates the animal and test tube research. Doses are between 200 mg and 2000 mg daily doses, but usually 500 mg to 1000 mg twice a day. So it's the equivalent of 30 pills per day, replaced by 2 bad-tasting drinks.
List of nutrients to be included in my next batch, not a-Syn blockers
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fisetin (strawberries)
apigenin (chamomile, parsley, celery, and in bee products, an MAO-AB inhibitor)
nobiletin (from citrus, may not include if the taste is too bad)
hesperidin (citrus, etc, very common)
Heptamethoxyflavone HMF (citrus)
citicoline (helps memory in AD, dopamine receptors, is bioavailable, neuroprotective, hormones (TSH, GH, TSH)
a-Syn blockers to be included (bioavailability possible but not known by me):
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naringin (the grapefruit bitterness)
gallic acid (from nutgall, black tea, teas, grapes, berries)
myricetin (bayberry bark)
morin (guava, osage)
Nordihydroguaiaretic acid
Genistein (ginseng)
cuminaldehyde (cumin)
quercetin (apples)
Considering:
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inosine (raises urate, should not take too much, raises activity of other compounds)
Tangeretin (tangerine, very expensive but requires only 1/5 as much as others)
alpha-lipoic acid
acetyl-L-carnitine
NAC
creatine
CoQ10
black tea extract (in case gallic acid is the not the primary benefit)
rutin (like quercetin)
peperine (for increasing bioavailability of some, hot taste will be tough to swallow straight)
Works or may work in PD and advisable in my opinion and not listed above included:
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Best evidence: nicotine (causes temporary imbalance and nausea), vitamins A, B's, D, E, fish oil, omega 3's from canola or flax, zinc, magnesium, melatonin, caffeine, 5-HTP, an NSAID like aspirin or ibuprofen, ellagic acid in olive and canola oil.
Whole extracts or foods: blueberry, apple, strawberry, teas, grape seed, beer, sardines.
Others with possibility: Co-Q10, theanine, selenium. Less evidence for: Mucuna pruriens, fava/broad beans, Bacopa monnieri, Gotu Kola, Ashwagandha. Bioavailable? PQQ, resveratrol, curcumin.
Not part of my a-Syn blockers/breakers listed above due to questions about bioavailability
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baicalein (skullcap flower, oxidized this breaks up existing a-Syn possibly like no other, seems completely unable to make it past liver to brain)
berberine (not strongly bioavailable, but can be helped with verapamil)
rosmarinc acid blocks a-Syn aggregation, but does not appear to be bioavailable.
resveratrol
curcuminoids
palmitoylethanolamide (PEA) is not orally bioavailable. (increases neurosteroidgenisis, affects cannaboid receptors, reduces inflammation and pain, improves mouse model for PD "Our results indicate that the PEA is neuroprotective even when administered once the insult has been initiated." ncbi.nlm.nih.gov/pmc/articl...
Pharmaceuticals useful in PD:
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L-DOPA, rasagiline, Ritalin, SSRI anti-depressants, synthetic triterpenoids, statins, ferriprox (iron chelator for PD), Nilotinib/Bafetinib/Dasanitib ($100,000 per year)
Warnings about drug interactions (not complete). These will amplify or reduce effects of some drugs by affecting liver enzymes. See the links for which pharmaceuticals are affected. This is more important than "grapefruit" interactions because the doses I want to take are very very high compared to grapefruit.
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quercetin: en.wikipedia.org/wiki/CYP2C8
piperine, curcumin, baicalein: en.wikipedia.org/wiki/CYP3A4
quercetin, naringin, naringenin, hesperitin: en.wikipedia.org/wiki/CYP1A2 and en.wikipedia.org/wiki/CYP3A4
apigenin: en.wikipedia.org/wiki/CYP2C9
tangeretin, nobiletin: SULT1A1
quercetin, naringin: SULT1A3 which increases beta(2) agonists (asthma)
Taking peperine, curcumin, naringin, and baicalein at same time can amplify each other.
Blocking CYP1A2 increases rasagiline
ncbi.nlm.nih.gov/pubmed/265...
notes:
citrulline: could not find support for it.
