I recently started taking 3 and then 6 mg of melatonin before bed and it seems to help a great deal. 18 years ago if I took more than about 0.25 mg it would make me really groggy most of the next day. 6 mg these days only seems to make me sleep better and feel a lot better then next day. I do not sleep any longer but apparently I am sleeping a lot deeper. Maybe a time-release form could help me sleep longer. I also started wearing ear plugs to help sleep. Has anyone else had experience with melatonin at these doses? I'm going to try 9 mg tonight.
It doesn't just improve sleep, but has a lot of neuroprotective effects. They say it may be that P does not reduce ability to produce melatonin, but PD decreases the number of melatonin receptors.
Here's a good article on melatonin and PD
Here's another article on melatonin, but also has a short but good list of chemicals that work in animal models of PD, aimed at better mitochondrial function, but also most of them have other effects like iron-chelating, antioxidant, and preventing protein misfolding. I don't use the Resveratrol or Curcumin in the list because humans do not seem to allow them to get in the blood or brain nearly as well as animals.