We are continuing with the Rytary..every 4.5 hours during the day.. The 'ON' time is so much better; sometimes no 'OFF' time between dosing. We are still working to find the 'ideal' dosage, alternating between 95s and 145s... We definitely try to avoid eating an hour before and after taking...that seems to work the best for ensuring the medication takes effect regardless of whether we have protein or not. Medication kicks in within the first hour. Neurologist suggested taking three pills around 11PM for the night shift but this keeps my husband up all night. We have tried two capsules for the past two nights and that seems to work much better...would like to get that down to one if possible but we will tweak as we go. I noticed Rytary is now on the Medicare Formulary but the individual plans do not list pricing yet. We are still getting samples from the Neurologist but hopefully the pricing will be up soon. I read somewhere about watching when you take vitamins so I am working on the schedule for that. Hopefully some other users will give input soon. Good luck to all!