I've taken just about everything and not only do the drugs not work, I feel like with each, I'm taking a "Parkinson's pill" that gives me all the PD symptoms and does nothing to help mitigate the ones I've already got. In recent days it was Artane. I went from having a pronounced tremor on my right side to having a pronounced tremor everywhere -- legs, arms and head -- along with unsteadiness and balance problems, constipation, and weirdest of all, my mouth and face spontaneously contorting -- often when I'm in the middle of a word (then I sound like I'm speaking gibberish). The doc told me to quit taking Artane. But I can't understand why this happens, and the doc seems just as mystified (She is a surgical movement disorder specialist). Most of her other patients on Artane said it had no effect on them whatsoever, and a few have had relief from tremors but nothing else. What the heck is wrong with me? I had this response to Sinemet, Amantidine, and all those drugs, then Neurontin, Zonisamide, and Artane.