Has anybody suffered sudden worsening? Until May this Year I was on Sinemet 62.5 mg 4 times a day, Requip 5mg and Azilect. My only problem was fatigue, but my mobility was good, so my nurse advised me to gradually double my Sinemet to 125 mg 4 times daily.
I was fine on this until a couple of weeks ago when I started having sudden "off" times. Even the rest of the day I'm very slow, stiff and exhausted. I can't understand why I have suddenly worsened after doubling my Sinemet.
Anybody else found this? I would welcome any comments/advice.