I've had a few days where my PD symptoms were particularly annoying and the Sinemet was not as effective. On these occasions I ate a large amount of spinach or lentils (very high oxalate foods) the night before. I was wondering if there was a link. Not only do high-oxalate foods cause kidney stones but they can disrupt mitochondrial function and promote cell death. As we Parkies know, we've got to keep our mitochondria in good working order to keep what is left of our neurons!