I have been on Sinemet for six years - 800 mg currently - and now that the s/e are severely impacting on my life I am keen to find a way of reducing it. In particular, the dyskinesias are getting much worse. I can't be prescribed a dopamine agonist because of ICD previously. I have received a 200g jar of Zandopa - and just want to check out the insights of you good folks on this site to make sure that it will help me reduce my Sinemet safely. I have read that the Zandopa takes less time to kick than Sinemet, is longer in positive effect and causes minimal s/e. I was planning to start with a small amount of Zandopa and Sinemet CR. I have a post it from my internet searches that 2.2g of Zandopa is equivalent to 88mg of levadopa.