13/11/13. I am now 76 had tremor intensive PD since 2001. Started on Sinemet Feb 2012, 3x100, 5 hr apart, increased to 150 after 9 mo. Started wearing off march 2013 after 1.5 hours. Neuro seems stumped so I have started experimenting. For some reason my mornings are still OK - better than off-time. So now I start at noon, 1x100 Sinemet then 1x100 every hour until 8 pm, no off-time, can go 1 hr 15 min but no more. It concerns me that this may be too much for me (from 450 to 900 mg). I have tried 200 mg – no difference. It seems that it’s all about experimenting till you find the right dose, it seems no doc can predict that, but may be able to keep you out of trouble. I prefer to stay with the Sinemet for as long as possible without adding additional meds to cope with side effects. Does anyone out there have a better solution to try. It is a bit frustrating trying to remember to take an hourly dose. Can this schedule do harm? Any helpful suggestions are appreciated.