Selegiline a new drug for me!

[camper]

I went to see my neurologist last week and he suggested I started to take selegiline. I'm already taking madopar and reprinerole.

Is anyone else taking selegiline and what are your thoughts on this drug?.

[wifeofparky]

My husband took selegiline for a few years and it is supposed to slow down the progress of the disease.

[Dennis]

I have never heard of this drug/medication. Main purpose is to slow down parkinsonism?

My medication I take every 4 hours round the clock 7 days a week. Before the 4 hours

are up I can feel the tremers, weakness, dizziness, etc....Thanks for sharing. ````Dennis

[Pete-1]

Selegiline is an MAO-B inhibitor. It prevents dopamine from being metabolised after use so that there is more dopamine floating about for re-uptake and re-use.

Also supposed to have a mild anti-depressant effect.

I take it with Madopar (equivalent to Sinemet) and Pramipexole (Mirapex, Sifrol, Mirapexine). I cannot tell what difference it makes because I've never tried to manage without it. I suspect that my off-periods would come sooner without it - at a guess.

Type A MAOs had particular dietary requirements + other problems I can't remember what they were but the type B's do not.

[wifeofparky in reply to Pete-1]

Hubby was originally only on Sinemet. When we went to a MDS, he put him on the selegiline as well as Zoloft. Hubby felt the difference and was able to remain on the same dosages for over 4 years.

[blessed4431]

I will be starting on this in about two weeks. So I what yo think about it. let me know I also received a booklet from my dr about following a low tyramine diet

[camper]

Thanks for your replies. I've only been taking selegline for a few days. My husband reckons my walking has improved but I'm not so sure.

[fisherman]

I give up on this site. I do not know what people are talking about or how it is supposed to work? You say share, inform and support. You definitely share but I have no idea where the inform and support comes in. I do not understand and I am sure I am not the only one who is not informed by this site or how it supports the average person?

[blessed4431]

Fisherman,The information comes from experience of those taking the the medication. We do support each other. I learn a lot and deeply appreciate the support and hearing what others experience. I have had a positive experience with this group I hope you give it some more time. I believe you will find this group helpful.

[camper in reply to blessed4431]

I've been taking selegline for a month now but no improvement in my gait freezing.Are you taking selegline yet and if so how are you getting on with it?

[Johnson]

Well fisherman I know how feel - which way do you turn, so many drugs and now its a question about selegiline - what's right for you is not right for me. It is a matter of trial and error with the approved meds. I get by with what I take but I also suffer. Next time I visit my Neurologist (June) I'll hit him with a lot of questions because this website has given me is a wealth of information and support for others. I wanted to get on LDN but hit a brick wall so far. We have to stop or minimise the inflammation in the brain that's causing all the damage and then wait patiently for the genetic repair mechanisms - Research and trials are heading down this path but I haven't heard how successful any of the clinical trials have been (on PD sufferers) but as soon as anything is announced you will find some reference to it here. There are people on this site who could treat PD symptons better than those in the medical profession. If you want to know anything about PD its all here - Cheers.

[skinnibean]

Ive been on Selegeline for the last 7 years, still on 2 x 100mg Sinamet per day and doing really well, I really recommend it.

[Kayyyyuz in reply to skinnibean]

Hi

How many hours is your on period after taking the selegiline and sinemet? Also how do you take them? For example do you take sinemet first then selegiline to block after one hour? What's the selegiline dosage?

I'm keen to learn from you as I'm hoping to start soon

Thanks

Kay

[skinnibean in reply to Kayyyyuz]

Kay, Ive always taken the two meds together in the morning, lasts for approx 3 hours, then just Sinamet late afternoon, so I can prepare myself a meal, (I live alone)

but recently I stopped taking Selegiline as it makes me drowsy, which I was getting fed up with. The dosage I was on was 5mg. I spend the afternoon switched off, this probably would not suit everyone, but I am very resistant to increasing dosages, and have happily managed on a low dose for years.

[Kayyyyuz in reply to skinnibean]

Wow! Sounds like what I do but without selegiline! I take Zandopa 2 scoop which kicks in after 20 minutes, then I'd take 500mg green tea capsule after 1 hour I make sure I do rigorous exercises like long brisk walk and weights then once I'm back I eat after 2 hours in all I stay on for 4 hours! If I want it longer day 6 hours I take sinemet cr 50/200mg instead of green tea or both, that way I get 7 hours on time!

But I'm thinking of trying selegiline then see if I can get benefits I read online like neuro protection etc

If you can try my green tea method let me know how you see it

Cheers

Kay

[skinnibean in reply to Kayyyyuz]

Ive never heard of Zandopa and only thought Green tea was a drink. I might investigate. I am currently experimenting with B1 to find my optimum dose, plus taking bio identical hormones, which keep my mood up.

I'm very impressed with your exercise regime, I do Boxing and walking, when I feel like it. Cheers Rebecca

[Kayyyyuz in reply to skinnibean]

Zandopa is a brand of Mucuna made in India. Yes I take B vitamins once a week

All the best!