Zoledronate has been repeatedly shown to give excellent control of overactive bone cells in Paget's Disease of Bone and is also effective for pain arising directly from the condition. There is a wealth of evidence to show its benefits. All drugs have risks and it is the minority of patients who suffer from side-effects of treatment. It would be good to hear, via this forum, from the majority who have a positive experience of treatment. We draw your attention to the following paper published in the Journal of Bone Mineral Research: A Single Infusion of Zoledronic Acid Produces Sustained Remissions in Paget Disease: Data to 6.5 Years. Ian R Reid, Kenneth Lyles, Guoqin Su, Jacques P Brown, John P Walsh, Javier del Pino-Montes, Paul D Miller, William D Fraser, Susan Cafoncelli, Christina Bucci-Rechtweg, David J Hosking (2012) Sep; 26(9):2261-70.