I have been on Imbruvica for 3 years now and it appears to be working as my lab numbers are all in the normal range now. Even my platelets went from 118-140 in a 3 month period. But I am wondering if swollen legs and feet could be caused by this medication. I have a swollen right foot and leg that is enlarged up to the knee. Doctors have me in compression stockings that do not seem to work. Have done kidney labs. It seems there is a small amt of microscopic blood in urine but otherwise, ultrasound shows kidneys and liver at normal size. Legs have been scanned with no abnormalities. I cannot lay around all day with my legs elevated above my heart and cannot be on fluid pills all the time as I have a job, etc. Is anyone else having this problem?