I have been receiving treatment for ovarian cancer for 16 months now, and after chemotherapy and radical debulking surgery I am now taking Niraparib. My CA125 was a steady 27 until I had my first COVID jab, when it started to rise. It went to 33,42,53. Then I had my second jab and it rose to 119 in just over a week. Six weeks after the second jab it is now 232. My CT scans show no changes though so I am wondering if the jab could have affected the CA125, the oncologist is mystified. I just wondered if this has happened to anyone else? Any comments would be much appreciated. Thanks.
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JanL100
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Hi there. A lot of women are seeing an increase in their numbers after the Covid jab. It generally decreases back down on the next blood test. My mums has gone to 27 from 19. She is due the next blood test in a few weeks.
I know that’s not much help but an insight into my mums results so far.
Hi - my PET scan was clear and my ca125 was 8 in March - it increased to 10 in April after first Pfizer vaccine - then to 17 in May after the second vaccine. I also started Olaparib in April. My oncologist said she feels it is likely combo of inflammation from both the vaccines and PARP. I’m anxious but hopeful. Good thoughts that we both soon see our ca125 lower!!
Hi, Following Pfizer vaccine, mine went from, 10 to 12, 17, & then 28. Iam on the parp Rubraca. Tomorrow I am due a blood test, and result on Thursday, so fingers crossed. I hope things improve for you.
Hi there, mine has been pretty stable on the whole when I had the vaccines, but did rise a couple of points too. However, I had Covid in April of last year and it went from 18 to 39 in the period of around a month. As my symptoms finally resolved with the Covid, my CA 125 went back down to normal again, over a period of around 4-6 weeks. I do believe the jabs may well be responsible.
Hi Jan, I was rough with it for well over a month but thankfully, no after effects. The worse thing at the time was my CA125 going up, it really scared me. However, I was so happy when it started to gradually recede.
Mine have gone sky high since the first jab. Three months later they are starting to creep down a little. Getting a scan at the end of the month to see what is happening with cancers. I am also on Niraparib. Best wishes to you x
Mine went up slightly after my jab, but came down on next blood test. I am due another blood test at the end of June and had my 2nd Jab about a month ago . So lm hoping its not done anything on this 2nd jab. But l honestly dont think its anything to worry about. SheilaFxxx
I finished Chemo on October and been on 200mg of Niraparib since early December. It ticked up in very small increments until the first jab then doubled then doubled again.
I am on 4 weekly blood tests so get regular readings. I had a CT scan a few weeks ago which was clear apart from one of the lymph nodes which may be inflamed because of the vaccine (I hope).
I have since had the second jab and am waiting on my bloods from yesterday but expect a further rise which I hope is not a recurrence. ❤️
Hi, thank you for your reply. It sounds as though we have the same issues. Good luck with your results. It’s definitely starting to look like the jab is the problem 🤞🏻
Hi Jan, I too have been experiencing high CA-125 numbers. Had 2nd vaccine end of April and in June my 125 went from 28 to 51 and five days later to 53. Went into a total panic, three years ago ovarian cancer was the last thing on my mind. Had an emergency CT Scan in June and it came back, once again "clear, disease free". Went for another CA-125 in July and it was 66. Once again I'm in a panic.
My oncologist doesn't want to see me until September, which is a good thing as one of us isn't in a panic. He is very good and keeps up with all the new medical advances and news. So I do trust him, he hasn't steered me wrong yet.
Hi, it’s great to know that it’s not just me! Mine went up to 225 a couple of weeks ago which was a worry but last week it was 400. However I have been off Niraparib for 5 weeks and have been taking multivitamins. I have just discovered that that can also affect the Ca125 so I’m not taking anymore until I’ve had another blood test in 2 weeks. It sounds like you’ve got a great oncologist. I hope all’s well in September.
I can see you have had lots of informative responses to your post from the forum community so just wanted to pop by and share this resource about the role of CA125. I hope this may be useful for you.
The Foundation for Women’s Cancer are a non-for-profit organisation based in the U.S, who support research, education, and public awareness of gynaecological cancers. They published a booklet in 2017 titled ‘CA-125 levels: Your guide’ which explains more about CA-125 and how it is used in a clinical setting. It’s available to view via their website here: foundationforwomenscancer.o....
As this is a U.S resource, the organisations listed at the end may not be as relevant for our U.K/ non-U.S members.
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Rising Ca125 on Niraparib
Rising CA125 but clear scan. 
CA125 ALREADY RISING 
