My daughter has had JRA since11 years old and currently takes mtx. She is doing quite well on it. She went into remission for 2 yrs with no meds and had a flare and is back on mtx. She is special needs and 17yrs old now. The arthritis affects her knees but she remains active. She takes mtx mixed with oj so she does not get the nasty size effects as well as folic acid. I hope she will outgrow it.