Third primary dose - Covid Antibody result: Hi everyone... - NRAS

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Third primary dose - Covid Antibody result

Rachhfost profile image
39 Replies

Hi everyone

I know there has been lots of posts on this but I thought I would add my latest result.

I’m on methotrexate (22.5) and Humira.

After 2 Astra Zeneca doses I had very low antibody result 19.6 u/ml and was told by rheumatologist to be very cautious.

I had third dose (Pfizer) nearly 3 weeks ago and just got my result - >2,500 u/ml. I paused all medication for 2 weeks prior and 2 weeks after

I’m so relieved that I can now start to live life a little more normally. Hope others on here can do the same.

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Rachhfost profile image
Rachhfost
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39 Replies
springcross profile image
springcross

That's great news Rachhfost, I'm really pleased for you. x

Lolabridge profile image
Lolabridge

Excellent news - you must be very relieved 😌

Boxerlady profile image
Boxerlady

👌

MadBunny profile image
MadBunny

Fantastic news. And what a relief for you 👍😁

Potatos profile image
Potatos

Thanks for sharing.

wishbone profile image
wishbone

That's good to hear. I think the higher overall efficacy of pfizer and moderna compared to astrazeneca is a lot to do with the former two being the vaccines of choice for the booster and 3rd vaccine regardless of which vaccine people had before. Ideally the extremely vunerable should have had the pfizer as their first 2 jabs, but it's understandable that most did not as the government wanted as many people as possible vaccinated quickly. All in my humble opinion of course. :-)

Neonkittie17 profile image
Neonkittie17 in reply to wishbone

It’s exactly my view too. If Pfizer has more efficacy and as immunocompromIsed we are likely to have a lowered immune respond so that makes perfect sense to give people like us the Pfizer as third.

Rachhfost profile image
Rachhfost in reply to Neonkittie17

I completely agree with this too. All the studies say that AZ provokes a less robust immune response that also wanes more quickly, I’m certain that is at least part of the reason UK is in a much worse situation than other European countries right now. We used much more AZ and vaccinated earlier so we have lots of vulnerable people right now.

Neonkittie17 profile image
Neonkittie17 in reply to Rachhfost

I agree with you entirely, Rach, but the UK wasn’t going to not use the vaccine it created and had the most of to roll out. As soon as I read about the lesser efficacy it was thought to have, I thought .. wouldn’t it be better and most sensible and safer to give that to the immunosuppressed?

Rachhfost profile image
Rachhfost in reply to Neonkittie17

Absolutely. And I was very happy to have the ‘Oxford’ vaccine at the time. It’s still a great vaccine protecting millions. But I was also very happy to have the Pfizer third dose and delighted with the new antibody result 💪🏼 I just hope that the most vulnerable get their booster or third dose sooner rather than later because whatever Sajid Javid says, nearly a thousand deaths a week is not “mercifully low”

Knip profile image
Knip in reply to Rachhfost

I agree with your comment whole heartedly Rachhfrost. 👍

Neonkittie17 profile image
Neonkittie17 in reply to Rachhfost

Hi, I hope people get theirs too Rachel and feel better for doing that. I can’t have mine until I’ve got B cells back and I’ve no antibodies [Rituximab scuppered my vaccines] so it’s a waiting game for me. I understand fully people wanting their third vaccines ASAP. I want mine repeated ASAP too but I’m rather a frustrating case. x

hatshepsut profile image
hatshepsut

Unfortunately, I had the third astrazenec, won't get my booster until 6 months later. Tried to get Phizer, according to the green book, no, has to be the same as previous twoSo ONS came to do the blood test 3 weeks ago, 10 days after jab.

Results came yesterday

Zero antibodies Gutted

Monkeysmum profile image
Monkeysmum in reply to hatshepsut

Sorry to hear this Hatshepsut 😥

Rachhfost profile image
Rachhfost in reply to hatshepsut

I’m so, so sorry to hear this. I don’t understand why you were told you had to have AZ again. What meds are you on if you don’t mind me asking?

hatshepsut profile image
hatshepsut in reply to Rachhfost

MTX, abatacept, hydroxychloroquine. Stopped MTX and biologic for 2 weeks.

wishbone profile image
wishbone in reply to hatshepsut

Can'tsay I'd be very happy about that either. I wonder if there's a problem with the pfizer vaccine due to the very low temps needed to store it. Just a thought.

AgedCrone profile image
AgedCrone in reply to wishbone

Pfizer vaccine can now be stored for one month in a regular refrigerator.

wishbone profile image
wishbone in reply to AgedCrone

So it can. Do you know why all the publicity , especially earlier in the pandemic, saying it needs to be stored in extremely cold temps like dry ice or whatever? Can't say I recall hearing it can be kept in a fridge for up to one month.

AgedCrone profile image
AgedCrone in reply to wishbone

Could it be to justify the huge price difference between it & the other competing vaccines? There are still people in this funny old world who think the more you have to pay for something….the better it must be!

In fact I believe it was because the research had been done so quickly they hadn’t tested it for the necessary length of time to see if it really did need such low temperatures permanently.

wishbone profile image
wishbone in reply to AgedCrone

Could well be. GPs don't appear to be administering the booster, which up until now I thought might be to do with the difficulty storing pfizer vaccine in cold enough temps. Whereas a decent sized domestic fridge/freezer from Currys will do the job just fine. There's probably a bit more to it than that though.

AgedCrone profile image
AgedCrone in reply to wishbone

If you think about it….there must be a minimum time to leave a new vaccine at lower temps than it had already been tested at…..& at the beginning of Covid 19 vaccine distribution, it was vital to get vaccines into people…they didn’t have the luxury of waiting around to see how long before it became useless.That was the advantage of the AZ vaccine…it’s base had been tried & tested many times.

wishbone profile image
wishbone in reply to AgedCrone

I appreciate that, my comment was directed at GPs and the current pfizer booster. Of course GP surgeries may well be too busy with other things such as the flu vaccine roll out to take on booster jabs as well.

AgedCrone profile image
AgedCrone in reply to wishbone

Or even seeing sick people who have been waiting ages for af2f appointment?Plus do they have a priority list for either the 3rd Primary Vaccine ir the booster?

GP’s don’t get to choose which vaccine they are supplied with…in my area they just told us which they were providing….& if you wanted a different one…you waited until that came along.

Hopefully most people have been taking advantage of getting their Flu jabs at a pharmacy…they started their clinics early September.

Knip profile image
Knip in reply to hatshepsut

I really feel for you. Could you let your GP know and see if they will re-vaccinate you using the Pfizer? It would make sense for them to do so. Hope you get some help regarding it...God Bless, x

hatshepsut profile image
hatshepsut in reply to Knip

Thankyou....I am going to talk to my gp about this. I did everything I could, stopped my MTX for 2 weeks, plus my biologic. Hopefully something can be done, if not I will write to the Health Minister.

sule profile image
sule

I'm on Infliximab and Methotrexate. After two doses of Astra Zeneca, I had monthly antibody tests with every result coming back as negative for antibodies. My booster jab was Pfizer and I have tested positive for antibodies! I stopped Methotrexate for 1 week before jab and 1 week after. This was my decision even though Rheumatology told me to continue all medication as usual. Sometimes you have to follow your instinct!

CagneysMum profile image
CagneysMum in reply to sule

I’m thinking the same but can’t decide whether to stop one week either side or for two weeks after. How did you decide?

sule profile image
sule in reply to CagneysMum

My methotrexate was due on the day of the Covid jab so didn't take it then. I then missed the one which followed the jab. To be honest I just hedged my bets, with missing one before and one after! Do what you feel happy with. Missing two doses for me didn't affect my joints but I know that if I miss three doses it will.

CagneysMum profile image
CagneysMum in reply to sule

Hi. I know I’m ok missing two doses so have arrived at the same decision as you.

Ascidian profile image
Ascidian in reply to sule

I started mtx just one week before my first covid jab, so asked rheumy team 3 times should i wait till after my first jab before starting meds. 3 times they said no.Obviously i only had a small amount of mtx in my system for the first jab, but was on 20mg by the 2nd one. I did produce some antibodies, but not as many as I would have liked. So when i finally get my booster I am going to stop mtx for 2 weeks, whatever the rheumy says.

Tile profile image
Tile

You should try to get the quantitative result, or the actual number as above 2500 can be from a low of 2501 to much higher 20,000 IU/ml plus. These antibodies can take deep plunges within a few months usually less than 6 months, going from 20,000 to 10, 000 isn't bad, but 2501 could take a plunge to under 500, even under 100 IU/ml.

It's hard to tell if you need to boost this 3rd dose with a 4th SOONER without getting the actual number.

Otto11 profile image
Otto11

That’s great news. I too had first two doses of Astrozenica & my 3rd primary is tomorrow 🤞they give me Pfizer as my letter says as I also had zero antibodies in July & caught Covid in August. X

Haz58 profile image
Haz58

My Rheumy nurse said not to take methotrexate for 2 weeks at least after my Pfizer booster jab. I really wish they would give everyone all over the country the same advice, it would stop all the confusion!

Knip profile image
Knip in reply to Haz58

It would help, wouldn't it Haz58, if they were all of the same mind! It's so confusing otherwise.

Evie3 profile image
Evie3

Good news! Did the Dr check your antibodies?

CagneysMum profile image
CagneysMum

Agree that some protection is better than none but in hindsight I would not have chosen (if I’d had any choice!) to receive AZ vaccination.

I’m starting to feel hopeful about booking a holiday next year and was looking at USA but they are not currently recognizing Astra Zenica as being appropriately vaccinated against Covid. Same for some of the American cruise lines like Celebrity and Royal Carribean. So they will not allow me passage there. It will be interesting to see if a third jab of Pfizer changes this perspective ??

BonnieG123 profile image
BonnieG123

Great news!!!

GinnyE profile image
GinnyE

Same here. >2500. Paused methotrexate 20mg for two weeks after jab. I'm off to see my nephew today, the first time since June. Feel a bit nervous actually!

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